Evidence map›Paper›PMID 37883229›Full record

ArticleCell reports2023

PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.

Kun Ho Kim, Stephanie N Oprescu, Madigan M Snyder, Aran Kim, Zhihao Jia, Feng Yue, Shihuan Kuang

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Lipid droplets as cell fate determinants in skeletal muscle.Trends in endocrinology and metabolism: TEM · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kun Ho KimDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Stephanie N OprescuDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Madigan M SnyderDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Aran KimDepartment of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Zhihao JiaDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Feng YueDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: skuang@purdue.edu.
Purdue University West Lafayette · US

Funding

Immunomyoblasts in muscle regenerationR01AR078695 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2021 to 2025
$2.2M
Metabolic regulation of muscle satellite cell homeostasisR01DK132819 · NIDDK · PURDUE UNIVERSITY · PI Shihuan Kuang · 2023 to 2026
$2.0M
Targeting PTEN to ameliorate muscular dystrophy in a mouse modelR01AR079235 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2022 to 2025
$1.3M
Sox11 function in muscle stem cellsF31AR077424 · NIAMS · PURDUE UNIVERSITY · PI OPRESCU, STEPHANIE NICOLE · 2020 to 2022
$114k
NIAMS NIH HHS F31 AR077424NIAMS NIH HHS R01 AR078695NIAMS NIH HHS R01 AR079235NIDDK NIH HHS R01 DK132819
6 · The paper itself

Abstract

Development is regulated by various factors, including protein methylation status. While PRMT5 is well known for its roles in oncogenesis by mediating symmetric di-methylation of arginine, its role in normal development remains elusive. Using Myod1

Indexed as

MyoblastsProtein-Arginine N-MethyltransferasesAnimalsAutophagyCell DifferentiationForkhead Box Protein O1MethylationMiceForkhead Box Protein O1Foxo1 protein, mousePrmt5 protein, mouseProtein-Arginine N-MethyltransferasesautophagyCP: Developmental biologyCP: Molecular biologymyogenesisposttranslational modificationPRMTprotein arginine methyltransferasePTMsatellite cellsSCs

Identifiers

PMID37883229
PMCPMC10727913
OpenAlexW4387966391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.