Evidence map›Paper›PMID 37882968›Full record

Observational studyLangenbeck's archives of surgery2023

Does month of birth influence colorectal cancer prognosis?

José Martín-Arévalo, David Moro-Valdezate, Vicente Pla-Martí, Stephanie García-Botello, Pablo Moya-Marcos, Ana Izquierdo-Moreno, Leticia Pérez-Santiago, David Casado-Rodrigo, Susana Roselló-Keränen, Alejandro Espí-Macías

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

José Martín-ArévaloColorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain.
David Moro-ValdezateColorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain. david.moro@uv.es.ORCID http://orcid.org/0000-0003-0425-8677
Vicente Pla-MartíColorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain.
Stephanie García-BotelloColorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain.
Pablo Moya-MarcosDepartment of Surgery, University of Valencia, Valencia, Spain.
Ana Izquierdo-MorenoColorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain.
Leticia Pérez-SantiagoColorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain.
David Casado-RodrigoColorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain.
Susana Roselló-KeränenDepartment of Medical Oncology, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Alejandro Espí-MacíasColorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain.
Universitat de València · ESHospital Clínico Universitario de Valencia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe main aim of this study was to identify a possible association between month of birth of colorectal cancer (CRC) patients and overall survival (OS) or disease-free survival (DFS).

methodsThis observational study included all consecutive adult patients diagnosed with CRC undergoing oncological surgery from January 2005 to December 2019 with a minimum follow-up of 10 years. The outcome variables were locoregional recurrence, death due to cancer progression, OS and DFS. Non-supervised learning techniques (K-means) were conducted to identify groups of months with similar oncologic outcomes. Finally, OS and DFS were analysed using Kaplan-Meier and Cox regression tests. The model was calibrated with resampling techniques and subsequently a cross-validation was performed.

resultsA total of 2520 patients were included. Three birth month groups with different oncologic outcomes were obtained. Survival analysis showed between-group differences in OS (p < 0.001) and DFS (p = 0.03). The multivariable Cox proportional hazards model identified the clusters obtained as independent prognostic factors for OS (p < 0.001) and DFS (p = 0.031).

conclusionThere is an association between month of birth and oncologic outcomes of CRC. Patients born in the months of January, February, June, July, October and December had better OS and DFS than those born in different months of the year.

Indexed as

Colorectal NeoplasmsResearch DesignAdultDisease-Free SurvivalHumansPrognosisColorectal cancerMonth of birthPrognosisSurvival

Identifiers

PMID37882968
PMCPMC10602963
OpenAlexW4387950169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.