Evidence map›Paper›PMID 37881852›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023

The effect of oscillatory hemodynamics on the cardiovascular responses to simulated hemorrhage during isocapnia.

Garen K Anderson, K Austin Davis, Nasrul Bhuiyan, Ryan Rusy, Alexander J Rosenberg, Caroline A Rickards

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Garen K AndersonDepartment of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.
K Austin DavisDepartment of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0002-1277-6266
Nasrul BhuiyanDepartment of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Ryan RusyDepartment of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Alexander J RosenbergDepartment of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Caroline A RickardsDepartment of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0002-5759-6912
University of North Texas · US

Funding

Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026
$6.9M
Development of a clinically-relevant test for assessment of cerebral vascular functionF32HL144082 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROSENBERG, ALEXANDER · 2019 to 2021
$149k
NHLBI NIH HHS F32 HL144082NIA NIH HHS T32 AG020494
6 · The paper itself

Abstract

During cerebral hypoperfusion induced by lower body negative pressure (LBNP), cerebral tissue oxygenation is protected with oscillatory arterial pressure and cerebral blood flow at low frequencies (0.1 Hz and 0.05 Hz), despite no protection of cerebral blood flow or oxygen delivery. However, hypocapnia induced by LBNP contributes to cerebral blood flow reductions, and may mask potential protective effects of hemodynamic oscillations on cerebral blood flow. We hypothesized that under isocapnic conditions, forced oscillations of arterial pressure and blood flow at 0.1 Hz and 0.05 Hz would attenuate reductions in extra- and intracranial blood flow during simulated hemorrhage using LBNP. Eleven human participants underwent three LBNP profiles: a nonoscillatory condition (0 Hz) and two oscillatory conditions (0.1 Hz and 0.05 Hz). End-tidal (et) CO

Indexed as

HemodynamicsHypocapniaArterial PressureBlood Flow VelocityBlood PressureCerebrovascular CirculationHemorrhageHumansLower Body Negative PressureMiddle Cerebral Artery0.1 Hzcerebral blood flowcerebral oxygenationlower body negative pressureoscillations

Identifiers

PMID37881852
PMCPMC10911761
OpenAlexW4387948447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.