Evidence map›Paper›PMID 37881843›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2023

The role of mild stressors in children's cognition and inflammation: positive and negative impacts depend on timing of exposure.

Marta Francesconi, Amedeo Minichino, Eirini Flouri

Abstract readComment
In one paragraph

Article in European psychiatry : the journal of the Association of European Psychiatrists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Marta FrancesconiDepartment of Psychology and Human Development, Institute of Education, University College London, London, UK.ORCID 0000-0001-9751-5219
Amedeo MinichinoDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-6309-6324
Eirini FlouriDepartment of Psychology and Human Development, Institute of Education, University College London, London, UK.

Funding

Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Wellcome Trust 217065/Z/19/Z
6 · The paper itself

Abstract

Although the impact of stressful life events (SLEs) on mental health is well-established, the research on the impact of such stressors on cognitive outcomes has produced mixed results. Arguably, the timing and severity of exposure may play a key role. In this study, we shed light on the relationship between timing of exposure to relatively minor SLEs and cognitive ability in children, while taking into account the role of a plausible biological mediator: inflammation. Using data from the Avon Longitudinal Study of Parents and Children, a general population birth cohort, we explored the role of relatively minor SLEs, experienced during two crucial developmental stages: up to transition to school (1-4.5 years) and up to transition to puberty (5.5-8.5 years). We then tested if they may impact differently on inflammatory markers (serum C-reactive protein [CRP] and interleukin 6 [IL-6]) at age 9 and general intelligence, measured with the Wechsler Abbreviated Scale of Intelligence at age 15. Data (

Indexed as

InflammationInterleukin-6AdolescentChildCognitionC-Reactive ProteinHumansLongitudinal StudiesC-Reactive ProteinInterleukin-6ALSPACcognitive abilitiesinflammationpreschool agestressful life events

Identifiers

PMID37881843
PMCPMC10755563

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.