Evidence map›Paper›PMID 37881837›Full record

ArticleHaematologica2024

BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics.

Rongqing Aaron Pan, Youzhen Wang, Shumei Qiu, Mariana Villalobos-Ortiz, Jeremy Ryan, Erick Morris, Ensar Halilovic, Anthony Letai

Abstract readLetter
In one paragraph

Article in Haematologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Pandora's Box of AML: HowBiomedicines · 2025
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rongqing Aaron PanBone Marrow Transplantation Center of the First Affiliated Hospital and Institute of Hematology and Department of Immunology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215.
Youzhen WangNovartis Institute of Biomedical Research, Oncology Drug Discovery, Cambridge, MA 02139.
Shumei QiuNovartis Institute of Biomedical Research, Oncology Drug Discovery, Cambridge, MA 02139.
Mariana Villalobos-OrtizDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA ; Harvard Medical School, Boston, MA 02215.
Jeremy RyanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA ; Harvard Medical School, Boston, MA 02215.
Erick MorrisNovartis Institute of Biomedical Research, Oncology Drug Discovery, Cambridge, MA 02139.
Ensar HalilovicNovartis Institute of Biomedical Research, Oncology Drug Discovery, Cambridge, MA 02139.
Anthony LetaiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA ; Harvard Medical School, Boston, MA 02215. Anthony_Letai@dfci.harvard.edu.

Funding

TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
Reading mitochondrial apoptotic signaling to identify active cancer therapeuticsR35CA242427 · NCI · DANA-FARBER CANCER INST · PI LETAI, ANTHONY G · 2019 to 2025
$7.0M
NCI NIH HHS P01 CA066996NCI NIH HHS R35 CA242427
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsProto-Oncogene Proteins c-bcl-2ApoptosisCell Line, TumorHumansPeptide FragmentsProto-Oncogene ProteinsAntineoplastic AgentsPeptide FragmentsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2

Identifiers

PMID37881837
PMCPMC10985422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.