Evidence map›Paper›PMID 37881706›Full record

ArticleNanoscale advances2023

Fabrication of membrane proteins in the form of native cell membrane nanoparticles using novel membrane active polymers.

Thi Kim Hoang Trinh, Claudio Catalano, Youzhong Guo

Open access · goldAbstract read
In one paragraph

Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Advances in native cell membrane nanoparticles system.Current opinion in structural biology · 2025
    Review
  2. Cholesterol-dependent enzyme activity of human TSPO1.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thi Kim Hoang TrinhDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University Richmond VA 23298 USA yguo4@vcu.edu.ORCID https://orcid.org/0000-0002-9906-5896
Claudio CatalanoDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University Richmond VA 23298 USA yguo4@vcu.edu.
Youzhong GuoDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University Richmond VA 23298 USA yguo4@vcu.edu.ORCID https://orcid.org/0000-0001-7177-9603
Virginia Commonwealth University · US

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Proposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-22-017R01GM132329 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI GUO, YOUZHONG · 2019 to 2022
$1.9M
NCI NIH HHS P30 CA016059NIGMS NIH HHS R01 GM132329NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

Membrane proteins are a widespread class of bio-macromolecules responsible for numerous vital biological processes and serve as therapeutic targets for a vast array of contemporary medications. For membrane protein isolation and purification, detergents have historically been used. Despite this, detergents frequently result in protein instability. Consequently, their application was limited. Recent detergent-free approaches have been invented. Among these, styrene-maleic acid lipid particle (SMALP), diisobutylene-maleic acid lipid particle (DIBMALP), and native cell membrane nanoparticle (NCMN) systems are the most prevalent. The NCMN system intends to create a library of membrane-active polymers suitable for high-resolution structure determination of membrane protein. Design, synthesis, characterization, and comparative application evaluations of three novel classes of NCMN polymers, NCMNP13-

Identifiers

PMID37881706
PMCPMC10597567
OpenAlexW4387466808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.