ArticleBiological psychiatry global open science2023
Increased Aperiodic Neural Activity During Sleep in Major Depressive Disorder.
Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Brain rhythms of depression: A predictive processing perspective.Trends in neurosciences · 2026Review
- Age-Related Differences and Effects of Internalizing Symptoms on Aperiodic Neural Activity in Adolescents.Psychophysiology · 2026Article
- Power Spectral Slope as a Novel Brain Functional Marker for Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- Temporally resolved analyses of aperiodic features track neural dynamics during sleep.Communications psychology · 2025Article
- Analysis of aperiodic activity in obsessive-compulsive disorder and major depression.Scientific reports · 2025Article
- Alterations in aperiodic neural activity associated with major depressive disorder.Nature. Mental health · 2025Article
- Aperiodic neural activity distinguishes between phasic and tonic REM sleep.Journal of sleep research · 2025Article
- Aperiodic (1/f) Neural Activity Robustly Tracks Symptom Severity Changes in Treatment-Resistant Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Article
- Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity.PLoS computational biology · 2024Article
- Neurophysiological avenues to better conceptualizing adaptive cognition.Communications biology · 2024Article
- Article
- Delta-Beta Coupling in Adolescents with Depression: A Preliminary Examination of Associations with Age, Symptoms, and Treatment Outcomes.Journal of psychophysiology · 2024Article
- Aperiodic neural activity is a biomarker for depression severity.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In major depressive disorder (MDD), patients often express subjective sleep complaints, while polysomnographic studies report only subtle alterations of the electroencephalographic signal. We hypothesize that differentiating the signal into its oscillatory and aperiodic components may bring new insights into our understanding of sleep abnormalities in MDD. Specifically, we investigated aperiodic neural activity during sleep and its relationships with sleep architecture, depression severity, and responsivity to antidepressant treatment. Methods: Polysomnography was recorded in 38 patients with MDD (in unmedicated and 7-day-medicated states) and 38 age-matched healthy control subjects ( Results: Unmedicated patients showed flatter aperiodic slopes compared with control subjects during non-rapid eye movement (non-REM) stage 2 sleep ( Conclusions: Flatter slopes of aperiodic electroencephalographic power may reflect noisier neural activity due to increased excitation-to-inhibition balance, representing a new disease-relevant feature of sleep in MDD.
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