ArticleBiological psychiatry global open science2023
Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study.
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Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Prior Sexual Violence, PTSD Symptoms, and Recovery Trajectories After New Trauma.JAMA psychiatry · 2026Article
- Article
- Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Posttraumatic Stress Disorder-Related Differences in Neural Connectivity Among Female Trauma Survivors.Biological psychiatry global open science · 2025Article
- Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models.Molecular psychiatry · 2025Review
- Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.Nature. Mental health · 2025Article
- Traumatic stress alters neural reactivity to visual stimulation.NPP - digital psychiatry and neuroscience · 2025Article
- PTSD-related differences in resting-state functional connectivity and associations with sex hormones.medRxiv : the preprint server for health sciences · 2024Article
- Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study.Psychological medicine · 2024Article
- Childhood Maltreatment and Amygdala-Mediated Anxiety and Posttraumatic Stress Following Adult Trauma.Biological psychiatry global open science · 2024Article
- Child sexual abuse versus adult sexual assault: A review of psychological and neurobiological sequelae.Mental health science · 2024Article
- Disentangling sex differences in PTSD risk factors.Nature. Mental health · 2024Article
- Neighborhood Disadvantage and Neural Correlates of Threat and Reward Processing in Survivors of Recent Trauma.JAMA network open · 2023Article
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Authors and funding
49 authors at 20 institutions in 2 countries.
Grace E RowlandDivision of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts.
Alyssa RoecknerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Timothy D ElyDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Lauren A M LeboisDivision of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, Missouri.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri.
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, Rhode Island.
Xinming AnInstitute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Thomas C NeylanDepartment of Psychiatry, University of California, San Francisco, San Francisco, California.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia.
Sarah D LinnstaedtInstitute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Laura T GermineDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Scott L RauchDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, Michigan.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida.
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, New Jersey.
Brittany E PunchesDepartment of Emergency Medicine, Ohio State University College of Medicine, Columbus, Ohio.
Michael C KurzDepartment of Emergency Medicine, University of Alabama School of Medicine, Birmingham, Alabama.
Nina T GentileDepartment of Emergency Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Lauren A HudakDepartment of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia.
Jose L PascualDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Mark J SeamonPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Erica HarrisEinstein Medical Center, Philadelphia, Pennsylvania.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, Michigan.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Robert M DomeierDepartment of Emergency Medicine, Saint Joseph Mercy Hospital, Ypsilanti, Michigan.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts.
Paulina SergotDepartment of Emergency Medicine, McGovern Medical School at UTHealth, Houston, Texas.
Leon D SanchezDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Mark W MillerNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, Massachusetts.
Robert H PietrzakNational Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, Connecticut.
Jutta JoormannDepartment of Psychology, Yale University, New Haven, Connecticut.
Diego A PizzagalliDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts.
John F SheridanDivision of Biosciences, Ohio State University College of Dentistry, Columbus, Ohio.
Jordan W SmollerDepartment of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts.
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan.
James M ElliottKolling Institute, University of Sydney, St. Leonards, New South Wales, Sydney, Australia.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts.
Karestan C KoenenDepartment of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, Boston, Massachusetts.
Samuel A McLeanDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Kerry J ResslerDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Nathaniel G HarnettDivision of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts.
Harvard University · USEmory University · USUniversity of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USUniversity of Florida · USUniversity of Missouri–St. Louis · USWayne State University · USYale University · USBaystate Medical Center · USBoston University · USBroad Institute · USBrown University · USCooper Medical School of Rowan University · USEinstein Medical Center Philadelphia · USGeorgia Institute of Technology · USHenry Ford Health System · USHospital of the University of Pennsylvania · USIndiana University School of MedicineMcLean Hospital · USMercy Medical Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MLongitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8MEarly Life Stress and Depression: Molecular and Functional Imaging ApproachesR01MH095809 · NIMH · MCLEAN HOSPITAL · PI DU, FEI, PIZZAGALLI, DIEGO A · 2012 to 2024
$6.4MNeuromuscular Mechanisms Underlying Poor Recovery from Whiplash InjuriesR01HD079076 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COURTNEY, D. MARK, ELLIOTT, JAMES MATTHEW · 2014 to 2018
$1.6MCharacterizing the Neurobiology of Pathological Dissociation: Mechanisms of Face Perception and Self Referential ProcessingK01MH118467 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2019 to 2022
$679kA Multidimensional Neuroimaging Investigation of Posttraumatic Stress in HumansK00MH119603 · NIMH · MCLEAN HOSPITAL · PI HARNETT, NATHANIEL G · 2018 to 2021
$311kMRI and machine learning to improve early prognosis and clinical management after spinal cord injuryR03HD094577 · NICHD · UNIVERSITY OF COLORADO DENVER · PI SMITH, ANDREW CRAIG · 2019 to 2020
$195kSOCIAL SUPPORT OF CAREGIVERS FOR DEMENTIA PATIENTSF33AG005654 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI SOKOLOVSKY, JAY H · 1994 to 1994
–NCATS NIH HHS UL1 TR001863NIA NIH HHS F33 AG005654NICHD NIH HHS R01 HD079076NICHD NIH HHS R03 HD094577NIMH NIH HHS K00 MH119603NIMH NIH HHS K01 MH118467NIMH NIH HHS R01 MH095809NIMH NIH HHS U01 MH110925
Abstract
Background: Prior sexual trauma (ST) is associated with greater risk for posttraumatic stress disorder after a subsequent traumatic event; however, the underlying neurobiological mechanisms remain opaque. We investigated longitudinal posttraumatic dysfunction and amygdala functional dynamics following admission to an emergency department for new primarily nonsexual trauma in participants with and without previous ST. Methods: Participants ( Results: Prior ST was associated with greater posttraumatic depression ( Conclusions: Findings suggest that prior ST is associated with heightened posttraumatic dysfunction following a new trauma exposure but not increased amygdala activity. In addition, ST may interact with lifetime trauma load to alter neural circuitry in visual processing regions following acute trauma exposure. Further research should probe the relationship between trauma type and visual circuitry in the acute aftermath of trauma.
Indexed as
Longitudinal studyNeuroimagingPosttraumatic stress disorderSexual trauma
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