Evidence map›Paper›PMID 37881572›Full record

ArticleBiological psychiatry global open science2023

Low Dopamine D2 Receptor Expression Drives Gene Networks Related to GABA, cAMP, Growth and Neuroinflammation in Striatal Indirect Pathway Neurons.

Lucia Guerri, Lauren K Dobbs, Daniel A da Silva E Silva, Allen Meyers, Aaron Ge, Lea Lecaj, Caroline Djakuduel, Damien Islek, Dionisio Hipolito, Abdiel Badillo Martinez and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. PGx-BasedCurrent neuropharmacology · 2026
    Article
  2. Article
  3. Chronic Cocaine Use and Parkinson's Disease: An Interpretative Model.International journal of environmental research and public health · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Lucia GuerriLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Lauren K DobbsLaboratory on Neurobiology of Compulsive Behaviors, NIAAA, National Institutes of Health, Bethesda, Maryland.
Daniel A da Silva E SilvaLaboratory on Neurobiology of Compulsive Behaviors, NIAAA, National Institutes of Health, Bethesda, Maryland.
Allen MeyersLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Aaron GeUniversity of Maryland, College Park, Maryland.
Lea LecajLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Caroline DjakuduelLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Damien IslekLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Dionisio HipolitoLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Abdiel Badillo MartinezLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Pei-Hong ShenLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Cheryl A MariettaLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
Susanna P GaramszegiDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, Florida.
Enrico CapobiancoInstitute for Data Science and Computing, University of Miami, Miami, Florida.
Zhijie JiangInstitute for Data Science and Computing, University of Miami, Miami, Florida.
Melanie SchwandtOffice of the Clinical Director, NIAAA, National Institutes of Health, Bethesda, Maryland.
Deborah C MashDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, Florida.
Veronica A AlvarezLaboratory on Neurobiology of Compulsive Behaviors, NIAAA, National Institutes of Health, Bethesda, Maryland.
David GoldmanLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, Maryland.
National Institutes of Health · USUniversity of Miami · USUniversity of Maryland, College Park · US

Funding

Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6M
Synaptic mechanisms underlying reward seeking and compulsive drug useZIAAA000421 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI ALVAREZ, VERONICA A · 2009 to 2025
$23.1M
Integrative genetics with high throughput, multiplex genZ01AA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 1999 to 2008
$5.2M
Epigenetic Marks of Cocaine AddictionR01DA033684 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MASH, DEBORAH C., TURECKI, GUSTAVO · 2011 to 2015
$3.6M
PSYCHOPHARMACOLOGY OF ADOLESCENTS WITH AUD AND ADHDK24AA000301 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUKSTEIN, OSCAR G · 2001 to 2005
$494k
Intramural NIH HHS Z01 AA000301Intramural NIH HHS ZIA AA000301Intramural NIH HHS ZIA AA000421NIAAA NIH HHS K24 AA000301NIDA NIH HHS R01 DA033684
6 · The paper itself

Abstract

Background: A salient effect of addictive drugs is to hijack the dopamine reward system, an evolutionarily conserved driver of goal-directed behavior and learning. Reduced dopamine type 2 receptor availability in the striatum is an important pathophysiological mechanism for addiction that is both consequential and causal for other molecular, cellular, and neuronal network differences etiologic for this disorder. Here, we sought to identify gene expression changes attributable to innate low expression of the Methods: Cre-conditional, translating ribosome affinity purification (TRAP) was used to purify and analyze the translatome (ribosome-bound messenger RNA) of iMSNs from mice with low/heterozygous or wild-type Results: Innate low expression of Conclusions: This study provides strong molecular evidence that, in addiction, inhibition by the indirect pathway is constitutively enhanced through neural growth and increased GABA signaling.

Indexed as

AddictionDopamineDrd2Indirect pathwayPsychiatric disordersSubstance Use DisorderTranscriptomicsTRAP

Identifiers

PMID37881572
PMCPMC10593893
OpenAlexW4295206781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.