Evidence map›Paper›PMID 37881545›Full record

ArticleBiological psychiatry global open science2023

The Association Between Maternal Cortisol and Infant Amygdala Volume Is Moderated by Socioeconomic Status.

Max P Herzberg, Regina Triplett, Ronald McCarthy, Sydney Kaplan, Dimitrios Alexopoulos, Dominique Meyer, Jyoti Arora, J Philip Miller, Tara A Smyser, Erik D Herzog and 7 more

Open access · goldAbstract read
In one paragraph

Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Article
  4. Article
  5. Prenatal social disadvantage is associated with alterations in functional networks at birth.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Prenatal Stress and Maternal Role in Neurodevelopment.Annual review of developmental psychology · 2024
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Max P HerzbergDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
Regina TriplettDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri.
Ronald McCarthyDepartment of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri.
Sydney KaplanDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri.
Dimitrios AlexopoulosDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri.
Dominique MeyerDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri.
Jyoti AroraDepartment of Biostatistics, Washington University in St. Louis, St. Louis, Missouri.
J Philip MillerDepartment of Biostatistics, Washington University in St. Louis, St. Louis, Missouri.
Tara A SmyserDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
Erik D HerzogDepartment of Biology, Washington University in St. Louis, St. Louis, Missouri.
Sarah K EnglandDepartment of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri.
Peinan ZhaoDepartment of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri.
Deanna M BarchDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
Cynthia E RogersDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
Barbara B WarnerDepartment of Pediatrics, Washington University in St. Louis, St. Louis, Missouri.
Christopher D SmyserDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri.
Joan LubyDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
Washington University in St. Louis · US

Funding

Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental DisordersR01MH113883 · NIMH · WASHINGTON UNIVERSITY · PI JOAN L. LUBY, Christopher Daniel Smyser · 2018 to 2026
$20.6M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
NICHD NIH HHS P50 HD103525NIMH NIH HHS R01 MH113883NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

Background: It has been well established that socioeconomic status is associated with mental and physical health as well as brain development, with emerging data suggesting that these relationships begin in utero. However, less is known about how prenatal socioeconomic environments interact with the gestational environment to affect neonatal brain volume. Methods: Maternal cortisol output measured at each trimester of pregnancy and neonatal brain structure were assessed in 241 mother-infant dyads. We examined associations between the trajectory of maternal cortisol output across pregnancy and volumes of cortisol receptor-rich regions of the brain, including the amygdala, hippocampus, medial prefrontal cortex, and caudate. Given the known effects of poverty on infant brain structure, socioeconomic disadvantage was included as a moderating variable. Results: Neonatal amygdala volume was predicted by an interaction between maternal cortisol output across pregnancy and socioeconomic disadvantage (standardized β = -0.31, Conclusions: These data suggest that fetal development of the amygdala is differentially affected by maternal cortisol production at varying levels of socioeconomic advantage.

Indexed as

AmygdalaCortisolDevelopmentInfancyNeonatal MRISocioeconomic status

Identifiers

PMID37881545
PMCPMC10593881
OpenAlexW4353048119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.