Evidence map›Paper›PMID 37881437›Full record

ArticleFrontiers in immunology2023

L-methionine supplementation modulates IgM

Diana Martín, M Camino Ordás, Inês Carvalho, Patricia Díaz-Rosales, Noelia Nuñez-Ortiz, Samuel Vicente-Gil, Aitor Arrogante, Carlos Zarza, Marina Machado, Benjamín Costas and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Diana MartínFish Immunology and Pathology Laboratory, Animal Health and Research Center (CISA), National Institute for Agricultural and Food Research and Technology (INIA), Spanish National Research Council (CSIC), Madrid, Spain.
M Camino OrdásFish Immunology and Pathology Laboratory, Animal Health and Research Center (CISA), National Institute for Agricultural and Food Research and Technology (INIA), Spanish National Research Council (CSIC), Madrid, Spain.
Inês CarvalhoCentro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Matosinhos, Portugal.
Patricia Díaz-RosalesFish Immunology and Pathology Laboratory, Animal Health and Research Center (CISA), National Institute for Agricultural and Food Research and Technology (INIA), Spanish National Research Council (CSIC), Madrid, Spain.
Noelia Nuñez-OrtizFish Immunology and Pathology Laboratory, Animal Health and Research Center (CISA), National Institute for Agricultural and Food Research and Technology (INIA), Spanish National Research Council (CSIC), Madrid, Spain.
Samuel Vicente-GilFish Immunology and Pathology Laboratory, Animal Health and Research Center (CISA), National Institute for Agricultural and Food Research and Technology (INIA), Spanish National Research Council (CSIC), Madrid, Spain.
Aitor ArroganteFish Immunology and Pathology Laboratory, Animal Health and Research Center (CISA), National Institute for Agricultural and Food Research and Technology (INIA), Spanish National Research Council (CSIC), Madrid, Spain.
Carlos ZarzaSkretting Aquaculture Innovation, Stavanger, Norway.
Marina MachadoCentro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Matosinhos, Portugal.
Benjamín CostasCentro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Matosinhos, Portugal.
Carolina TafallaFish Immunology and Pathology Laboratory, Animal Health and Research Center (CISA), National Institute for Agricultural and Food Research and Technology (INIA), Spanish National Research Council (CSIC), Madrid, Spain.
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESConsejo Superior de Investigaciones Científicas · ESUniversidade do Porto · PTSkretting (Norway) · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interest in dietary amino acids (AAs) as potential immunomodulators has been growing the recent years, since specific AAs are known to regulate key metabolic pathways of the immune response or increase the synthesis of some immune-related proteins. Methionine, tryptophan and lysine are among the ten essential AAs for fish, meaning that they cannot be produced endogenously and must be provided through the diet. To date, although dietary supplementation of fish with some of these AAs has been shown to have positive effects on some innate immune parameters and disease resistance, the effects that these AAs provoke on cells of the adaptive immune system remained unexplored. Hence, in the current study, we have investigated the effects of these three AAs on the functionality of rainbow trout (

Indexed as

MethionineOncorhynchus mykissAnimalsDietary SupplementsImmunoglobulin MLipopolysaccharidesLysineRacemethionineTryptophanImmunoglobulin MLipopolysaccharidesLysineMethionineRacemethionineTryptophanamino acidsIgM + B cellslysinemethioninerainbow troutTNP-LPStryptophan

Identifiers

PMID37881437
PMCPMC10597660
OpenAlexW4387514237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.