Evidence map›Paper›PMID 37881407›Full record

ArticleContemporary clinical trials communications2023

The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milk.

Brooke Langevin, Mathangi Gopalakrishnan, Janae Kuttamperoor, John Van Den Anker, Jeanne Murphy, Kathleen F Arcaro, Dina Daines, Allison C Sylvetsky

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Article in Contemporary clinical trials communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brooke LangevinCenter for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, USA.
Mathangi GopalakrishnanCenter for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, USA.
Janae KuttamperoorDepartment of Exercise and Nutrition Sciences, The George Washington University, Washington D.C., USA.
John Van Den AnkerDivision of Clinical Pharmacology, Children's National Medical Center, Washington D.C., USA.
Jeanne MurphySchool of Nursing, The George Washington University, Washington D.C., USA.
Kathleen F ArcaroDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, USA.
Dina DainesDepartment of Obstetrics and Gynecology, The George Washington University, Washington D.C., USA.
Allison C SylvetskyDepartment of Exercise and Nutrition Sciences, The George Washington University, Washington D.C., USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Forty-four percent of lactating women in the United States consume beverages containing low calorie sweeteners (LCS), and the presence of LCS in the food supply has continued to increase in recent years. While LCS are approved by the United States Food and Drug Administration (FDA) and are believed to be safe for human consumption, intergenerational LCS transmission and the health impacts of early life LCS exposure are severely understudied. Methods and analysis: In a tightly controlled, single site, prospective interventional study, mothers' plasma and breast milk, and infants' plasma will be collected from 40 mother-infant dyads over the course of 72 h, with rich sampling following maternal ingestion of a LCS sweetened beverage containing sucralose and acesulfame potassium (ace-K). Concentration-time data will be used to build maternal and infant pharmacokinetic models for future simulations and analysis. Conclusion: This study aims to measure LCS concentrations in breast milk, maternal plasma, and infant plasma, to gain insight into infant exposure and inform recommendations for LCS consumption during breastfeeding.

Indexed as

Acesulfame-potassiumIntergenerational transmissionLow calorie sweetenersPharmacometricsSucralose

Identifiers

PMID37881407
PMCPMC10594547

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.