Evidence map›Paper›PMID 37881366›Full record

ArticleInternational journal of analytical chemistry2023

Structural Identification of Impurities in Pioglitazone Hydrochloride Preparations by 2D-UHPLC-Q-Exactive Orbitrap HRMS and Their Toxicity Prediction.

Dandan Zhang, Weijian Wang, Haiyun Zhao, Song Wang, Mingyan Yu, Dongmei Zhang, Wenkun Liu, Qiangsheng Xie, Dejun Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dandan ZhangShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.
Weijian WangShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.
Haiyun ZhaoShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.
Song WangShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.
Mingyan YuShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.
Dongmei ZhangShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.
Wenkun LiuShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.
Qiangsheng XieShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.
Dejun ChenShandong Institute for Food and Drug Control, Shandong Research Center of Engineering and Technology for Consistency Evaluation of Generic Drugs, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Public Service Platforms for Industrial Technology, Jinan, China.ORCID https://orcid.org/0009-0005-3840-9711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmaceutical companies and regulatory agencies have more and more concerns for impurities in pharmaceuticals and their toxicity. In this work, heart-cutting two-dimensional ultrahigh-performance liquid chromatography (2D-UHPLC) in combination with high-resolution mass spectrometry (HRMS) was used, setting HRMS as positive mode of electrospray ionization to identify five impurities in pioglitazone hydrochloride preparations. With the heart-cutting 2D-UHPLC and online desalting technique, the structures of five impurities were deduced in an analysis of MS

Identifiers

PMID37881366
PMCPMC10597724

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.