ArticleFrontiers in aging neuroscience2023
Enhanced brain functional connectivity and activation after 12-week Tai Chi-based action observation training in patients with Parkinson's disease.
Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Effects of mindfulness-based exercise on Parkinson's disease and Alzheimer's disease: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Tai Chi for improving motor symptoms in Parkinson's disease patients: a systematic review of mechanisms.Frontiers in aging neuroscience · 2026Pooled it
- The effectiveness of Tai Chi for patients with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Bilateral intermittent theta-burst stimulation as a priming strategy to enhance action observation and imitation training in early parkinson's disease: a proof-of-concept study.Journal of neuroengineering and rehabilitation · 2025Trial
- Repetitive Transcranial Magnetic Stimulation and Tai Chi Chuan for Older Adults With Sleep Disorders and Mild Cognitive Impairment: A Randomized Clinical Trial.JAMA network open · 2025Trial
- When Walking Outlasts Cognition: Rethinking the Late-Stage of Lewy Body Dementia.Neuro-degenerative diseases · 2026Review
- Quadrato Motor Training in Parkinson's Disease: Resting-State fMRI Changes and Exploratory Whole-Brain Radiomics.Bioengineering (Basel, Switzerland) · 2026Article
- Effect of Tai Chi combined with visual-action-sensory rehabilitation therapies on cognitive function in acute ischemic stroke: a study protocol for a randomized controlled trial.Annals of medicine · 2025Article
- Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders.BMC medical imaging · 2024Review
- Advancing the Frontier: Neuroimaging Techniques in the Early Detection and Management of Neurodegenerative Diseases.Cureus · 2024Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Motor-cognitive interactive interventions, such as action observation training (AOT), have shown great potential in restoring cognitive function and motor behaviors. It is expected that an advanced AOT incorporating specific Tai Chi movements with continuous and spiral characteristics can facilitate the shift from automatic to intentional actions and thus enhance motor control ability for early-stage PD. Nonetheless, the underlying neural mechanisms remain unclear. The study aimed to investigate changes in brain functional connectivity (FC) and clinical improvement after 12 weeks of Tai Chi-based action observation training (TC-AOT) compared to traditional physical therapy (TPT). Methods: Thirty early-stage PD patients were recruited and randomly assigned to the TC-AOT group ( Results: The results showed that the TC-AOT group exhibited significantly increased FCs between the dorsal medial prefrontal cortex and cerebellum crus I, between the posterior inferior parietal lobe and supramarginal gyrus, and between the temporal parietal junction and clusters of middle occipital gyrus and superior temporal. Moreover, these FC changes had a positive relationship with patients' improved motor and cognitive performance. Discussion: The finding supported that the TC-AOT promotes early-stage PD rehabilitation outcomes by promoting brain neuroplasticity where the FCs involved in the integration of sensorimotor processing and motor learning were strengthened.
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