ArticleEpilepsia open2024
Metabolic connectivity as a predictor of surgical outcome in mesial temporal lobe epilepsy.
Article in Epilepsia open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.
- Preoperative predictors of seizure outcomes after epilepsy surgery for mesial temporal sclerosis: A systematic review.Neurosurgical review · 2026Pooled it
- Preoperative [18F]FDG-PET Metabolic Patterns and Surgical Outcome in Mesial Temporal Lobe Epilepsy: A Retrospective SPM-Assisted Atlas-Based ROI Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Scalp fast oscillations detected by high-density EEG as a noninvasive predictor of surgical outcome in temporal lobe epilepsy with hippocampal sclerosis.Epilepsia open · 2026Article
- Metabolic connectivity and memory in mesial temporal lobe epilepsy.Brain communications · 2026Article
- Sleep and circadian rhythm disruptions in animal models of temporal lobe epilepsy.Frontiers in neuroscience · 2026Review
- Geometric representations of brain networks can predict the surgery outcome in temporal lobe epilepsy.NPJ systems biology and applications · 2025Article
- Metabolic connectivity as a predictor of surgical outcome in mesial temporal lobe epilepsy.Epilepsia open · 2024Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe study investigated metabolic connectivity (MC) differences between patients with unilateral drug-resistant mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) and healthy controls (HCs), based on [18 F]-fluorodeoxyglucose (FDG)-PET data. We focused on the MC changes dependent on the lateralization of the epileptogenic lobe and on correlations with postoperative outcomes.
methodsFDG-PET scans of 47 patients with unilateral MTLE with histopathologically proven HS and 25 HC were included in the study. All the patients underwent a standard anterior temporal lobectomy and were more than 2 years after the surgery. MC changes were compared between the two HS groups (left HS, right HS) and HC. Differences between the metabolic network of seizure-free and non-seizure-free patients after surgery were depicted afterward. Network changes were correlated with clinical characteristics.
resultsThe study showed widespread metabolic network changes in the HS patients as compared to HC. The changes were more extensive in the right HS than in the left HS. Unfavorable surgical outcomes were found in patients with decreased MC within the network including both the lesional and contralesional hippocampus, ipsilesional frontal operculum, and contralesional insula. Favorable outcomes correlated with decreased MC within the network involving both orbitofrontal cortices and the ipsilesional temporal lobe. SIGNIFICANCE: There are major differences in the metabolic networks of left and right HS, with more extensive changes in right HS. The changes within the metabolic network could help predict surgical outcomes in patients with HS. MC may identify patients with potentially unfavorable outcomes and direct them to a more detailed presurgical evaluation. PLAIN LANGUAGE SUMMARY: Metabolic connectivity is a promising method for metabolic network mapping. Metabolic networks in mesial temporal lobe epilepsy are dependent on lateralization of the epileptogenic lobe and could predict surgical outcomes.
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