Evidence map›Paper›PMID 37880997›Full record

SynthesisMultiple sclerosis (Houndmills, Basingstoke, England)2023

Safety of exercise training in multiple sclerosis: An updated systematic review and meta-analysis.

Yvonne C Learmonth, Matthew P Herring, Daniel I Russell, Lara A Pilutti, Sandra Day, Claudia H Marck, Bryan Chan, Alexandra P Metse, Robert W Motl

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Kinesiophobia in Multiple Sclerosis: Associations with Age, Anxiety, and Physical Activity.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
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  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yvonne C LearmonthSchool of Allied Health (Exercise Science), Murdoch University, Murdoch, WA, Australia.ORCID 0000-0002-4857-8480
Matthew P HerringPhysical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland.ORCID 0000-0002-6835-5321
Daniel I RussellDiscipline of Psychology, Murdoch University, Murdoch, WA, Australia.
Lara A PiluttiInterdisciplinary School of Health Sciences, Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-3074-4903
Sandra DayDiscipline of Psychology, Murdoch University, Murdoch, WA, Australia.
Claudia H MarckDisability and Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0002-3173-1522
Bryan ChanMurdoch University Library, Murdoch, WA, Australia.ORCID 0000-0001-5032-2815
Alexandra P MetseDiscipline of Psychology, School of Health, University of the Sunshine Coast, Sunshine Coast, QLD, Australia.
Robert W MotlDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.ORCID 0000-0002-5894-2290

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA review of the safety profile of exercise training in multiple sclerosis (MS) has not been conducted since 2013.

objectiveWe undertook a systematic review and meta-analysis of randomised controlled trials (RCTs) of exercise training published since 2013 and quantified estimated population risks of clinical relapse, adverse events (AE) and serious adverse event (SAE).

methodsArticles reporting safety outcomes from comparisons of exercise training with non-exercise among persons with MS were identified. The risk of bias was established from study's internal validity assessed using Physiotherapy Evidence Database (PEDro). Rates and estimated mean population relative risks (RRs; 95% confidence interval (CI)) of safety outcomes were calculated, and random-effects meta-analysis estimated the mean RR.

resultsForty-six interventions from 40 RCTs (

conclusionIn studies that reported safety outcomes, there was no higher risk of relapse, AE, adverse effects or SAE for exercise training than the comparator. Exercise training may be promoted as safe and beneficial to persons with MS.

Indexed as

ExerciseMultiple SclerosisChronic DiseaseExercise TherapyHumansRecurrenceadverse eventexercise trainingMultiple sclerosisrelapseserious adverse event

Identifiers

PMID37880997
PMCPMC10637110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.