Evidence map›Paper›PMID 37880992›Full record

ArticleAnnals of laboratory medicine2024

Head-to-Head Comparison of Nine Assays for the Detection of Anti-

Carolina Mattwich, Kristina Huber, Gisela Bretzel, Sebastian Suerbaum, Andreas Wieser, Karl Dichtl

Open access · diamondAbstract read
In one paragraph

Article in Annals of laboratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Diagnostic Pathways and Genotyping of Cases ofPathogens (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Carolina MattwichMax von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Medizinische Fakultät, LMU München, Munich, Germany.ORCID https://orcid.org/0009-0008-8793-3343
Kristina HuberDivision of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-8143-6313
Gisela BretzelDivision of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany.ORCID https://orcid.org/0009-0009-7102-3692
Sebastian SuerbaumMax von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Medizinische Fakultät, LMU München, Munich, Germany.ORCID https://orcid.org/0000-0001-9583-7505
Andreas WieserMax von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Medizinische Fakultät, LMU München, Munich, Germany.ORCID https://orcid.org/0000-0002-8703-9228
Karl DichtlMax von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Medizinische Fakultät, LMU München, Munich, Germany.ORCID https://orcid.org/0000-0001-5032-8870
Institute of Medical Microbiology and Hygiene · DELudwig-Maximilians-Universität München · DEFraunhofer Institute for Translational Medicine and Pharmacology · DEMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Echinococcosis is a neglected tropical disease that is severely underdiagnosed in resource-limited settings. In developed countries, diagnosing echinococcosis is challenging, and reliable serological assays are urgently needed. In the Central European Alps, EM is more common than EG; however, data on the diagnostic performance of assays for EM cases are scarce. We evaluated the suitability of nine antibody assays for routine diagnostics. Methods: Nine commercially available serological assays for detecting anti- Results: The performance of the assays varied greatly, with overall sensitivities ranging between 50% and 88% and specificities between 62% and 100%. We observed a trend toward better performance with cases classified as "confirmed" using the WHO-IWGE criteria. Combined analysis with sequential screening and confirmatory testing resulted in a maximum sensitivity of 84% and specificity of 100%. Differentiation between EG and EM infections is clinically relevant but was found to be unreliable. Conclusions:

Indexed as

EchinococcosisEchinococcusAnimalsAntibodies, HelminthEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GRetrospective StudiesSensitivity and SpecificityAntibodies, HelminthImmunoglobulin GAlveolar echinococcosisAntibodiesComparative studyCystic echinococcosisEchinococcosisEchinococcus granulosusEchinococcus multilocularisHydatidosisSerology

Identifiers

PMID37880992
PMCPMC10628756
OpenAlexW4387948792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.