Evidence map›Paper›PMID 37880687›Full record

ArticleBMC public health2023

Understanding covid-19 outcomes among people with intellectual disabilities in England.

Filip Sosenko, Daniel Mackay, Jill P Pell, Chris Hatton, Bhautesh D Jani, Deborah Cairns, Laura Ward, Angela Henderson, Michael Fleming, Dewy Nijhof and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Filip SosenkoThe University of Glasgow, Glasgow, UK. filip.sosenko@glasgow.ac.uk.
Daniel MackayThe University of Glasgow, Glasgow, UK.
Jill P PellThe University of Glasgow, Glasgow, UK.
Chris HattonManchester Metropolitan University, Manchester, UK.
Bhautesh D JaniThe University of Glasgow, Glasgow, UK.
Deborah CairnsThe University of Glasgow, Glasgow, UK.
Laura WardThe University of Dundee, Dundee, UK.
Angela HendersonThe University of Glasgow, Glasgow, UK.
Michael FlemingThe University of Glasgow, Glasgow, UK.
Dewy NijhofThe University of Glasgow, Glasgow, UK.
Craig MelvilleThe University of Glasgow, Glasgow, UK.
CVD-COVID-UK/COVID-IMPACT Consortium
University of Glasgow · GBManchester Metropolitan University · GBUniversity of Dundee · GB

Funding

British Heart Foundation SP/19/3/34678Medical Research Council MC_PC_20058
6 · The paper itself

Abstract

backgroundEvidence from the UK from the early stages of the covid-19 pandemic showed that people with Intellectual Disabilities (ID) had higher rates of covid-19 mortality than people without ID. However, estimates of the magnitude of risk vary widely; different studies used different time periods; and only early stages of the pandemic have been analysed. Existing analyses of risk factors have also been limited. The objective of this study was to investigate covid-19 mortality rates, hospitalisation rates, and risk factors in people with ID in England up to the end of 2021.

methodsRetrospective cohort study of all people with a laboratory-confirmed SARS-CoV-2 infection or death involving covid-19. Datasets covering primary care, secondary care, covid-19 tests and vaccinations, prescriptions, and deaths were linked at individual level.

resultsCovid-19 carries a disproportionately higher risk of death for people with ID, above their already higher risk of dying from other causes, in comparison to those without ID. Around 2,000 people with ID had a death involving covid-19 in England up to the end of 2021; approximately 1 in 180. The covid-19 standardized mortality ratio was 5.6 [95% CI 5.4, 5.9]. People with ID were also more likely to be hospitalised for covid-19 than people without ID. The main determinants of severe covid-19 outcomes (deaths and/or hospitalisations) in both populations were age, multimorbidity and vaccination status. The key factor responsible for the higher risk of severe covid-19 in the ID population was a much higher prevalence of multimorbidity in this population. AstraZeneca vaccine was slightly less effective in preventing severe covid-19 outcomes among people with ID than among people without ID.

conclusionsPeople with ID should be considered a priority group in future pandemics, such as shielding and vaccinations.

Indexed as

COVID-19Intellectual DisabilityEnglandHumansPandemicsRetrospective StudiesSARS-CoV-2Covid-19Intellectual DisabilitiesLearning disabilities

Identifiers

PMID37880687
PMCPMC10601171
OpenAlexW4387933685

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.