ArticleBMC ophthalmology2023
Central retinal artery occlusion without cherry-red spots.
Article in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Seeing It Through - Lessons from a Retinal Stroke Trial.The New England journal of medicine · 2026Article
- Impact of an eye-stroke protocol with non-mydriatic ocular imaging in an emergency department.Frontiers in neurology · 2026Article
- Automated detection of retinal artery occlusion in fundus photography via self-supervised deep learning and multimodal interpretability using a multimodal AI chatbot.Medical & biological engineering & computing · 2025Article
- Artificial Intelligence-Based Detection of Central Retinal Artery Occlusion Within 4.5 Hours on Standard Fundus Photographs.Journal of the American Heart Association · 2025Observational
- The Association Between Fundus Changes and Visual Prognosis in Central Retinal Artery Occlusion.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Vision recovery after ocular massage for cosmetic filler-induced ophthalmic artery occlusion.American journal of ophthalmology case reports · 2024Article
- A telemedicine-enabled intravenous thrombolytic treatment pathway for patients with hyperacute non-arteritic central retinal artery occlusion.American journal of ophthalmology case reports · 2024Article
- Central retinal artery occlusion or retinal stroke: a neurosonologist's perspective.Frontiers in neurology · 2024Article
- Purtscher-like retinopathy and paracentral acute middle maculopathy associated with improper antihypertensive drug use: a case report.Frontiers in medicine · 2024Article
- Retinal layer reflectivity and thickness as OCT biomarkers for diagnosis and imaging-based stratification relative to the 4.5-h window in acute central retinal artery occlusion.Frontiers in neurologyArticle
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCherry-red spots are a very important sign for the clinical diagnosis of central retinal artery occlusion (CRAO). We retrospectively summarized the clinical manifestations of CRAO and analysed the causes and characteristics of CRAO without cherry-red spots. In this study, we explored a diagnostic method for CRAO without cherry red spots.
methodsSeventy patients (70 eyes) with CRAO were examined retrospectively. Corrected distance visual acuity, fundus photos, FA and OCT images were collected at the first outpatient visit. The causes of CRAO without cherry-red spots were analysed through fundus photos. The incidence of increased hyperreflectivity of the inner retina, central macular thickness (CMT) and arteriovenous transit time in patients with and without cherry-red spots were compared.
resultsFundus examination showed posterior retinal whitening in 57 cases (81.43%) and cherry-red spots in 39 cases (55.71%). Thirty-one patients presented at the first outpatient visit without cherry-red spots. The reasons for the absence of cherry-red spots included leopard fundus (32.26%), retinal vein occlusion (25.81%), no obvious inner retinal coagulative necrosis (19.35%), ciliary retinal artery sparing (12.90%), high macular oedema (9.68%) and cherry-red spot enlargement (3.23%). OCT revealed increased hyperreflectivity of the inner retina in 67 CRAO patients (95.71%). All 3 patients without increased hyperreflectivity of the inner retina did not present with cherry-red spots at the first visit. The median CMT in patients without cherry-red spots was 166.00 μm, while the median MCT in patients with cherry-red spots was 180.00 μm; there was no significant difference between these two groups (P = 0.467). FA showed delayed arteriovenous transit time > 23 s in 20 patients (28.57%), > 15 s in 43 patients (61.43%) and no delay in 27 patients (30.77%). The median arteriovenous transit time in patients without cherry-red spots was 19.00 s, while it was 18.00 s in patients with cherry-red spots; there was no significant difference between these two groups (P = 0.727).
conclusionsThere are multiple factors that could cause the absence of cherry-red spots in CRAO. The use of OCT to observe increased hyperreflectivity of the inner retina is the most effective imaging method for the early diagnosis of CRAO without cherry-red spots.
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