ArticleNature2023
Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Metabolomic profiling of upper GI malignancies in blood and tissue: a systematic review and meta-analysis.Journal of cancer research and clinical oncology · 2024Pooled it
- Essentiality-driven prediction of anticancer drug responses in preclinical and clinical contexts.iScience · 2026Article
- UDP-Glucose-6-Dehydrogenase Mediated O-GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting UXS1-Dependent Glucuronate Detoxification Potentiates Metformin's Anti-Tumor Efficacy in Lung Adenocarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dynamic control of nucleotide metabolism in physiology and disease.Nature cell biology · 2026Review
- UDP-glucuronate decarboxylase 1 promotes tumor immune evasion by accelerating KMT2D loss in hepatocellular carcinoma.Journal for immunotherapy of cancer · 2026Article
- Stress adaptation pathways and HA-CD44 signaling maintain the survival of pancreatic cancer cells with centrosome amplification.Cell communication and signaling : CCS · 2026Article
- UXS1 Knockdown Suppresses Cell Proliferation and Invasion in Hepatocellular Carcinoma by Inducing Ferroptosis via SLC7A11/GPX4 Pathway.Current medical science · 2026Article
- Targeted metabolism creates possibilities for lung cancer treatment in the precision tumor era.Respiratory research · 2026Review
- Targeting NRF2 addiction in cancer: synthetic lethal strategies beyond direct inhibition.Frontiers in cell and developmental biology · 2026Review
- Serum proteomics and metabolomics reveal novel noninvasive molecular signatures for hepatocellular carcinoma diagnosis.Frontiers in oncology · 2026Article
- Metabolic enzyme-associated protein-protein interactions (mPPIs) in cancer: potential vulnerability for cancer treatment?Acta pharmacologica Sinica · 2025Review
- Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance.Matrix biology : journal of the International Society for Matrix Biology · 2025Article
- Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer.Cancer research · 2025Article
- Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets.Cancer discovery · 2025Article
- Circulating Protein Mediators Linking Genetically Predicted Smoking to Abdominal Aortic Aneurysm: A Genomic-Proteomic Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Uridine as a hub in cancer metabolism and RNA biology.Experimental & molecular medicine · 2025Review
- Pan-cancer analysis of UDP-glucose 6-dehydrogenase in human tumors and its function in hepatocellular carcinoma.World journal of gastrointestinal oncology · 2025Article
- Computational drug repurposing: approaches, evaluation of in silico resources and case studies.Nature reviews. Drug discovery · 2025Review
- Downregulation of UDP-glucose 6-dehydrogenase predicts adverse outcomes in patients with colorectal cancer and promotes tumorigenesis.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Mihir B DoshiDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-8449-8461
Namgyu LeeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Tenzin TseyangDepartment of Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Olga PonomarovaDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Hira Lal GoelDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Meghan SpearsDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Rui LiDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-3193-1396
Lihua Julie ZhuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-7416-0590
Christopher AshwoodGlycomics Core, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0001-5944-6179
Karl SiminDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-7431-0939
Cholsoon JangDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0001-6651-4213
Arthur M MercurioDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Albertha J M WalhoutDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-5587-3608
Jessica B SpinelliDepartment of Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-3657-4578
Dohoon KimDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. dohoon.kim@umassmed.edu.ORCID 0000-0002-5723-6589
University of Massachusetts Chan Medical School · USBeth Israel Deaconess Medical Center · USUniversity of California, Irvine · US
Funding
Transcription networks in C elegans organogenesisR01DK068429 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI A. J. Marian Walhout · 2005 to 2026
$10.9MGene regulatory and metabolic network structure, function and evolutionR35GM122502 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI A. J. Marian Walhout · 2017 to 2026
$8.3MElucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0MTargeting the detoxification function of the enzyme KDSR for cancer therapyR01CA269711 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Dohoon Kim · 2023 to 2026
$1.5MMechanisms of Carcinoma Initiation and DifferentiationR50CA221780 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GOEL, HIRA · 2018 to 2022
$1.1MGene Regulatory Networks in Development and PhysiologyR56DK068429 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WALHOUT, A. J. MARIAN · 2018 to 2018
$671kTransmission Electron Microscope for Core EM FacilityS10OD025113 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENDRICKS, GREGORY · 2018 to 2018
$600kUltramicrotomeS10OD021580 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENDRICKS, GREGORY · 2016 to 2016
$53kNCI NIH HHS R01 CA269711NCI NIH HHS R50 CA221780NIAAA NIH HHS R01 AA029124NIDDK NIH HHS R01 DK068429NIDDK NIH HHS R56 DK068429NIGMS NIH HHS R35 GM122502NIH HHS S10 OD021580NIH HHS S10 OD025113
Abstract
Identifying metabolic steps that are specifically required for the survival of cancer cells but are dispensable in normal cells remains a challenge
Indexed as
NeoplasmsUridine Diphosphate Glucuronic AcidAdenocarcinoma of LungHumansLung NeoplasmsSignal TransductionUridine Diphosphate XyloseUridine Diphosphate Glucuronic AcidUridine Diphosphate Xylose
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.