Evidence map›Paper›PMID 37880141›Full record

ArticleThe Journal of veterinary medical science2023

Oral 5-aminolevulinic acid combined with sodium ferrous citrate prevents blood-aqueous barrier breakdown after anterior chamber paracentesis in healthy beagle dogs.

Yuya Otaka, Kazutaka Kanai, Aoi Tomatsu, Riyo Sangu, Daiki Okada, Noriaki Nagai, Yohei Yamashita, Yoichiro Ichikawa, Aki Sakai, Kazuki Tajima

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuya OtakaDepartment of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Kazutaka KanaiDepartment of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Aoi TomatsuDepartment of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Riyo SanguDepartment of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Daiki OkadaDepartment of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Noriaki NagaiFaculty of Pharmacy, Kindai University, Osaka, Japan.
Yohei YamashitaDepartment of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Yoichiro IchikawaDepartment of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Aki SakaiOne Health Business Department, Companion Animal Group Neopharma Japan Co., Ltd., Tokyo, Japan.
Kazuki TajimaDepartment of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Kitasato University · JPKindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the preventive effect of 5-aminolevulinic acid combined with sodium ferrous citrate (5-ALA/SFC) on blood-aqueous barrier (BAB) breakdown induced after anterior chamber paracentesis (ACP) in beagles. 5-ALA/SFC (1/0.64 mg/kg or 3/1.92 mg/kg) or carprofen (4.0 mg/kg) was orally administered daily for 7 days prior to ACP. Then, a sample of the aqueous humor (AH) was collected from one eye via ACP (first sample) and again 60 min later (second sample). The protein and prostaglandin E2 (PGE2) concentrations in both samples were measured. Compared with the control group, high-dose 5-ALA/SFC and carprofen significantly reduced the AH protein and PGE2 concentrations in the second sample. Our findings suggest that 5-ALA/SFC suppresses BAB breakdown in dogs.

Indexed as

Blood-Aqueous BarrierParacentesisAminolevulinic AcidAnimalsAnterior ChamberAqueous HumorCitric AcidDinoprostoneDogsFerrous CompoundsAminolevulinic AcidCitric AcidDinoprostoneferrous citrateFerrous Compounds5-aminolevulinic acidanterior chamber paracentesisblood–aqueous barrierdogsodium ferrous citrate

Identifiers

PMID37880141
PMCPMC10788171
OpenAlexW4387868622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.