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ArticleEnvironmental research2024

Returning personal genetic information on susceptibility to arsenic toxicity to research participants in Bangladesh.

Lizeth I Tamayo, Syed Emdadul Haque, Tariqul Islam, Alauddin Ahmed, Moziber Rahman, Abu Horayra, Lin Tong, Lin Chen, Aresha Martinez-Cardoso, Habibul Ahsan and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05072132 (Returning Genetic Results on Arsenic Susceptibility to Bangladeshi Research Participants), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05072132 nacompletednot on this map

Returning Genetic Results on Arsenic Susceptibility to Bangladeshi Research Participants

TypeinterventionalSponsorUniversity of ChicagoRan2021 to 2023Enrolled300ConditionsArsenic ExposureArmsPersonal information on genetic susceptibility to arsenic toxicity, standard information on arsenic exposure reduction
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Lizeth I TamayoDepartment of Public Health Sciences, University of Chicago, Chicago, IL, 60615, USA.
Syed Emdadul HaqueUniversity of Chicago Research Bangladesh, Dhaka, Bangladesh.
Tariqul IslamUniversity of Chicago Research Bangladesh, Dhaka, Bangladesh.
Alauddin AhmedUniversity of Chicago Research Bangladesh, Dhaka, Bangladesh.
Moziber RahmanUniversity of Chicago Research Bangladesh, Dhaka, Bangladesh.
Abu HorayraUniversity of Chicago Research Bangladesh, Dhaka, Bangladesh.
Lin TongDepartment of Public Health Sciences, University of Chicago, Chicago, IL, 60615, USA.
Lin ChenDepartment of Public Health Sciences, University of Chicago, Chicago, IL, 60615, USA.
Aresha Martinez-CardosoDepartment of Public Health Sciences, University of Chicago, Chicago, IL, 60615, USA.
Habibul AhsanDepartment of Public Health Sciences, University of Chicago, Chicago, IL, 60615, USA; Department of Human Genetics, University of Chicago, Chicago, IL, 60615, USA; Department of Medicine, University of Chicago, Chicago, IL, 60615, USA.
Brandon L PierceDepartment of Public Health Sciences, University of Chicago, Chicago, IL, 60615, USA; Department of Human Genetics, University of Chicago, Chicago, IL, 60615, USA; Comprehensive Cancer Center, University of Chicago, Chicago, IL, 60615, USA. Electronic address: brandonpierce@uchicago.edu.
Chicago Department of Public Health · USUniversity of Chicago Research Bangladesh · BD

Funding

Chemoprevention of arsenic-induced skin cancerR01CA107431 · NCI · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2005 to 2014
$17.3M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Arsenic and the Human Genome: susceptibility and response to exposure Supplement 4R35ES028379 · NIEHS · UNIVERSITY OF CHICAGO · PI PIERCE, BRANDON LEE · 2017 to 2024
$5.6M
Genetics of arsenic metabolism: fine-mapping and rare variant analysisR01ES023834 · NIEHS · UNIVERSITY OF CHICAGO · PI PIERCE, BRANDON LEE · 2014 to 2017
$2.5M
A Study of Telomeres in an Arsenic-Exposed Bangladesh CohortR01ES020506 · NIEHS · UNIVERSITY OF CHICAGO · PI PIERCE, BRANDON LEE · 2011 to 2015
$1.9M
Enhancement and Maintenance of the HEALS cohortR24ES028532 · NIEHS · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2017 to 2022
$1.7M
Bangladesh Center for Global Environmental and Occupational HealthR24TW009555 · FIC · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2012 to 2014
$149k
FIC NIH HHS R24 TW009555NCI NIH HHS R01 CA107431NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES020506NIEHS NIH HHS R01 ES023834NIEHS NIH HHS R24 ES028532NIEHS NIH HHS R35 ES028379
6 · The paper itself

Abstract

backgroundThere is growing consensus that researchers should offer to return genetic results to participants, but returning results in lower-resource countries has received little attention. In this study, we return results on genetic susceptibility to arsenic toxicity to participants in a Bangladeshi cohort exposed to arsenic through naturally-contaminated drinking water. We examine the impact on behavioral changes related to exposure reduction.

methodsWe enrolled participants from the Health Effects of Arsenic Longitudinal Study who had (1) high arsenic (≥150 μg/g creatinine) in a recent urine sample and (2) existing data on genetic variants impacting arsenic metabolism efficiency (AS3MT and FTCD). We used genetic data to recruit three study groups, each with n = 103: (1) efficient metabolizers (low-risk), (2) inefficient metabolizers (high-risk), and (3) a randomly-selected control group (NCT05072132). At baseline, all participants received information on the effects of arsenic and how to reduce exposure by switching to a low arsenic well. The two intervention groups also received their arsenic metabolism efficiency status (based on their genetic results). Changes in behavior and arsenic exposure were assessed using questionnaires and urine arsenic measures after six months.

resultsClear decreases in urine arsenic after six months were observed for all three groups. The inefficient group self-reported higher levels of attempted switching to lower arsenic wells than the other groups; however, there was no detectable difference in urine arsenic reduction among the three groups. Participants showed strong interest in receiving genetic results and found them useful. The inefficient group experienced higher levels of anxiety than the other groups. Among the efficient group, that receiving genetic results did not appear to hinder behavioral change.

conclusionReturning genetic results increased self-reported exposure-reducing behaviors but did not have a detectable impact on reducing urine arsenic over and above a one-on-one educational intervention.

Indexed as

ArsenicArsenic PoisoningBangladeshGenetic PrivacyHumansLongitudinal StudiesMethyltransferasesArsenicAS3MT protein, humanMethyltransferasesArsenicBangladeshGenetic resultsInterventionLMIC

Identifiers

PMID37879393
PMCPMC10842833
OpenAlexW4387910202

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.