ArticleArquivos brasileiros de oftalmologia2023
Effect of levetiracetam on ocular perfusion measure with optical coherence tomography angiography.
Article in Arquivos brasileiros de oftalmologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Optical coherence tomography angiography in patients with focal epilepsy.Frontiers in neurology · 2025Article
- Toxic optic neuropathy associated with lamotrigine and levetiracetam dual therapy.BMJ case reports · 2024Article
- Ocular microvascular alterations in epileptic patients.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
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4 authors at 1 institution in 1 country.
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Abstract
purposeTo evaluate using optical coherence tomography angiography the macular and optic nerve head blood flow in pediatric patients with epilepsy treated with levetiracetam for at least 12 months.
methodsThis study included 33 pediatric patients with epilepsy and 30 sex- and age-matched healthy volunteer children were included in the study. Optical coherence tomography angiography was used to evaluate the optic nerve head and macular perfusion changes. The mean ocular perfusion pressures were also calculated. Patients who were using multiple antiepileptic drugs or had a prior history of using different drugs were excluded.
resultsThe choriocapillaris flow area was significantly lower in the Study Group than in the Control Group (p=0.006). However, the foveal avascular zone and vessel densities of the macula in the superficial capillary plexus, deep capillary plexus, and optic nerve head of the study group were not significantly different from those of the control group (p>0.05). Moreover, no significant difference in means of mean ocular perfusion pressure was found between the two groups (p=0.211). No obvious correlation was found between treatment duration and optical coherence tomography angiography parameters or mean ocular perfusion pressure.
conclusionChoroidal perfusion was reduced in children taking levetiracetam compared with that in the control group, whereas retinal perfusion was not affected in this optical coherence tomography angiography study.
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