Evidence map›Paper›PMID 37878813›Full record

SynthesisJNCI cancer spectrum2023

Sexual health outcomes among adolescent and young adult cancer patients: a systematic review and meta-analysis.

Niki Oveisi, Vicki Cheng, Lori A Brotto, Stuart Peacock, Helen McTaggart-Cowan, Gillian Hanley, Sharlene Gill, Meera Rayar, Amirrtha Srikanthan, Ursula Ellis and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in JNCI cancer spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Appraisal of sexual functioning before and after cancer: insights from adolescent and young adult (AYA) cancer survivors and matched healthy controls.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Review
  4. Nurses' attitudes toward addressing sexual health in their professional practice within cancer care: a Danish cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Sexuality, intimacy, and body image among adolescents and young adults with cancer: a qualitative, explorative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Niki OveisiFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Vicki ChengFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Lori A BrottoFaculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Stuart PeacockBC Cancer, Vancouver, BC, Canada.
Helen McTaggart-CowanBC Cancer, Vancouver, BC, Canada.
Gillian HanleyFaculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Sharlene GillFaculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Meera RayarFaculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Amirrtha SrikanthanFaculty of Medicine University of Ottawa, Ottawa, ON, Canada.
Ursula EllisUniversity of British Columbia Library, Vancouver, BC, Canada.
Mary A De VeraFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-2205-2683

Funding

CIHR
6 · The paper itself

Abstract

backgroundSexual health outcomes (SHO), which entail the physical, emotional, mental, and social impacts, are an important consideration for adolescent and young adults (AYA, ages 15-39) affected by cancer. The objective of this systematic review and meta-analysis is to summarize the current literature and evaluate AYA cancer impact on SHO.

methodsEMBASE and MEDLINE were searched from January 1, 2000 to September 28, 2022 to identify epidemiologic studies that used an analytic observational design, included individuals with AYA cancer and non-cancer control participants, and evaluated SHO. Odds ratios and prevalence ratios were calculated; random effects models were used to obtain pooled measures where possible.

resultsOf 2621 articles, 8 were included that investigated 23 SHO in 9038 AYA cancer patients. Based on the sexual response cycle, outcomes were categorized as those occurring among males (desire = 1, arousal = 1, orgasm = 4, other = 3) and females (desire = 2, arousal = 1, orgasm = 2, pain = 6, other = 3). It was feasible to conduct meta-analysis for 3 female SHO and 5 male SHO. There were associations between AYA cancer and 3 SHO: vaginal dryness (pooled odds ratio = 3.94; 95% confidence interval (CI) = 2.02 to 7.70), ejaculatory dysfunction (pooled odds ratio = 3.66; 95% CI = 2.20 to 6.08), and testosterone level (pooled mean difference = -2.56 nmol/liter; 95% CI = -3.46 to -1.66; P = .00001).

conclusionThis study found increased ejaculatory dysfunction and reduced testosterone levels in male AYA cancer patients and increased vaginal dryness in female AYA cancer patients, highlighting the need for sexual health resources in this population.

Indexed as

NeoplasmsSexual BehaviorAdolescentFemaleHumansMaleOrgasmOutcome Assessment, Health CareTestosteroneYoung AdultTestosterone

Identifiers

PMID37878813
PMCPMC10674049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.