ArticleProceedings of the National Academy of Sciences of the United States of America2023
Bacterial tolerance to host-exuded specialized metabolites structures the maize root microbiome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- How Useful Are Plant Traits in Explaining Variation in Phyllosphere Microbial Abundance and Composition Across Hosts?Environmental microbiology · 2025Pooled it
- Review
- Seed-borne bacteria-mediated seedling microbiome assembly: genetic and metabolic mechanisms of salt tolerance.Archives of microbiology · 2026Review
- Plant metabolic adaptation to nitrogen scarcity: the role of biological nitrification inhibitors.Essays in biochemistry · 2026Review
- Horizontal acquisition of nicotine catabolism gene cluster enhances Arthrobacter fitness within tobacco root microbiota.Microbiome · 2026Article
- Customizable High-Throughput Chemical Phenotyping of Root Bacteria.Bio-protocol · 2026Article
- Benzoxazinoid-mediated microbiome feedbacks enhance Arabidopsis growth and defence.The New phytologist · 2026Article
- Steering root-associated microbiomes via direct and soil legacy effects of neighbors.Microbiome · 2026Article
- Metabolome-driven rhizosphere microbiome assembly determining the health of medicinal herb (Angelica sinensis) against root rot.Microbiome · 2026Article
- Arbuscular Mycorrhizal Fungi Mitigate Drought-Enhanced Herbivore Performance in Maize.Plant, cell & environment · 2026Article
- Kaempferol drives genotype-specific microbiota Bacillaceae to enhance nitrogen acquisition in rapeseed.Journal of advanced research · 2026Article
- Structurally diverse biological nitrification inhibitors display distinct modes of inhibition in ammonia-oxidizing bacteria.FEMS microbiology ecology · 2026Article
- Mechanistic Insights for Microbiome Application in Plant Disease Resistance.Molecular plant pathology · 2026Review
- Root-knot nematode Meloidogyne incognita uses secondary-metabolite-mediated soil microbiome shifts to locate host plants.Nature plants · 2026Article
- Rhizosphere microbial shifts drive amygdalin detoxification and jasmonate-mediated alleviation of peach autotoxicity.The ISME journal · 2026Article
- Upregulated jasmonate signaling shifts Arabidopsis microbiota interactions and stress adaptations through a positive feedback loop.The ISME journal · 2026Article
- Mechanisms for the formation and maintenance of microhabitat self-organization in the root system of orchid.Frontiers in genetics · 2026Review
- Effects of cover cropping on orchard soil microbiomes: Mechanisms and perspectives.AIMS microbiology · 2026Review
- Microbial drivers of root plasticity.The New phytologist · 2025Review
- Synthetic communities of maize root bacteria interact and redirect benzoxazinoid metabolization.mSphere · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Plants exude specialized metabolites from their roots, and these compounds are known to structure the root microbiome. However, the underlying mechanisms are poorly understood. We established a representative collection of maize root bacteria and tested their tolerance against benzoxazinoids (BXs), the dominant specialized and bioactive metabolites in the root exudates of maize plants. In vitro experiments revealed that BXs inhibited bacterial growth in a strain- and compound-dependent manner. Tolerance against these selective antimicrobial compounds depended on bacterial cell wall structure. Further, we found that native root bacteria isolated from maize tolerated the BXs better compared to nonhost Arabidopsis bacteria. This finding suggests the adaptation of the root bacteria to the specialized metabolites of their host plant. Bacterial tolerance to 6-methoxy-benzoxazolin-2-one (MBOA), the most abundant and selective antimicrobial metabolite in the maize rhizosphere, correlated significantly with the abundance of these bacteria on BX-exuding maize roots. Thus, strain-dependent tolerance to BXs largely explained the abundance pattern of bacteria on maize roots. Abundant bacteria generally tolerated MBOA, while low abundant root microbiome members were sensitive to this compound. Our findings reveal that tolerance to plant specialized metabolites is an important competence determinant for root colonization. We propose that bacterial tolerance to root-derived antimicrobial compounds is an underlying mechanism determining the structure of host-specific microbial communities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.