Evidence map›Paper›PMID 37878672›Full record

ArticleScience translational medicine2023

Genetic vulnerability to Crohn's disease reveals a spatially resolved epithelial restitution program.

Toru Nakata, Chenhao Li, Toufic Mayassi, Helen Lin, Koushik Ghosh, Åsa Segerstolpe, Emma L Diamond, Paula Herbst, Tommaso Biancalani, Shreya Gaddam and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Toru NakataCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-3678-4807
Chenhao LiCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-1182-6804
Toufic MayassiCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-5458-1352
Helen LinCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-1823-1232
Koushik GhoshCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0009-0003-4666-3678
Åsa SegerstolpeKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-3700-9661
Emma L DiamondCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0009-0009-7482-9122
Paula HerbstCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Tommaso BiancalaniGenentech, South San Francisco, CA 94080, USA.ORCID 0000-0001-9104-9755
Shreya GaddamGenentech, South San Francisco, CA 94080, USA.
Saurabh ParkarGenentech, South San Francisco, CA 94080, USA.
Ziqing LuGenentech, South San Francisco, CA 94080, USA.ORCID 0000-0002-0921-6807
Alok JaiswalKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-1910-4681
Bihua LiKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Elizabeth A CreaseyCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-9724-7979
Ariel LefkovithKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-4519-0429
Mark J DalyKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-0949-8752
Daniel B GrahamCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-8403-8115
Ramnik J XavierCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-5630-5167
Broad Institute · USHarvard University · USKaiser Permanente South San Francisco Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Systematic dissection of gut cellular circuits [at single cell resolution]RC2DK114784 · NIDDK · BROAD INSTITUTE, INC. · PI ASHENBERG, ORR, GRAHAM, DANIEL BARTHOLOMEW · 2017 to 2021
$9.0M
NCI NIH HHS P30 CA008748NIDDK NIH HHS P30 DK043351NIDDK NIH HHS RC2 DK114784
6 · The paper itself

Abstract

Effective tissue repair requires coordinated intercellular communication to sense damage, remodel the tissue, and restore function. Here, we dissected the healing response in the intestinal mucosa by mapping intercellular communication at single-cell resolution and integrating with spatial transcriptomics. We demonstrated that a risk variant for Crohn's disease, hepatocyte growth factor activator (HGFAC) Arg

Indexed as

Crohn DiseaseAnimalsCell DifferentiationEpithelial CellsHumansIntestinal MucosaMiceSignal Transduction

Identifiers

PMID37878672
PMCPMC10798370
OpenAlexW4387949704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.