Evidence map›Paper›PMID 37878664›Full record

ArticleEnvironmental science & technology2023

Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA).

Vishal Midya, Jamil M Lane, Chris Gennings, Libni A Torres-Olascoaga, Jill K Gregory, Robert O Wright, Manish Arora, Martha Maria Téllez-Rojo, Shoshannah Eggers

Open access · hybridAbstract read
In one paragraph

Article in Environmental science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. An Exploration of Machine Learning Methods in Human Biomonitoring.International journal of environmental research and public health · 2026
    Review
  4. Article
  5. Article
  6. Zinc and Cobalt exposure influencebioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. iScience · 2024
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Vishal MidyaDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.ORCID 0000-0002-6643-5176
Jamil M LaneDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Chris GenningsDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Libni A Torres-OlascoagaCenter for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca 62100, Mexico.
Jill K GregoryInstructional Technology Group, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Manish AroraDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Martha Maria Téllez-RojoCenter for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca 62100, Mexico.
Shoshannah EggersDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Icahn School of Medicine at Mount Sinai · USInstituto Nacional de Salud Pública · MXUniversity of Iowa · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2014 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
Research Training Program in Pediatric ExposomicsT32HD049311 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2007 to 2026
$7.4M
Early Warning Systems for Childhood and Adult DisordersR35ES030435 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2020 to 2026
$6.7M
The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) CohortR24ES028522 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Megan K Horton, Maria Jose Rosa · 2017 to 2026
$1.8M
Early life metal exposure, the gut microbiome, and neurodevelopment in childhoodR00ES032884 · NIEHS · UNIVERSITY OF IOWA · PI EGGERS, SHOSHANNAH IYLENE · 2023 to 2025
$727k
Early life metal exposure, the gut microbiome, and neurodevelopment in childhoodK99ES032884 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EGGERS, SHOSHANNAH IYLENE · 2022 to 2023
$210k
NCATS NIH HHS UL1 TR004419NICHD NIH HHS T32 HD049311NIEHS NIH HHS K99 ES032884NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES032884NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R24 ES028522NIEHS NIH HHS R35 ES030435
6 · The paper itself

Abstract

Many analytical methods used in gut microbiome research focus on either single bacterial taxa or the whole microbiome, ignoring multibacteria relationships (microbial cliques). We present a novel analytical approach to identify microbial cliques within the gut microbiome of children at 9-11 years associated with prenatal lead (Pb) exposure. Data came from a subset of participants (

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAluminum SilicatesBacteriaChildFemaleHumansLeadPregnancyAluminum SilicatesLeadmicaCausal inferenceExposomeGut microbiomeMachine learningMetal exposureMicrobial co-occurrenceProbiotic

Identifiers

PMID37878664
PMCPMC10634322
OpenAlexW4387934478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.