Evidence map›Paper›PMID 37878417›Full record

ArticleCancer biology & therapy2023

Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance.

David J Zahavi, Rossin Erbe, Yong-Wei Zhang, Theresa Guo, Zoe X Malchiodi, Rachael Maynard, Alexander Lekan, Rosa Gallagher, Julia Wulfkuhle, Emanuel Petricoin and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancer biology & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

David J ZahaviDepartment of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.
Rossin ErbeDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, USA.
Yong-Wei ZhangDepartment of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.
Theresa GuoDepartment of Oncology, UC San Diego School of Medicine, San Diego, USA.
Zoe X MalchiodiDepartment of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.
Rachael MaynardDepartment of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.
Alexander LekanDepartment of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.
Rosa GallagherCenter for Applied Proteomics and Molecular Medicine, George Mason University, Fairfax, USA.
Julia WulfkuhleCenter for Applied Proteomics and Molecular Medicine, George Mason University, Fairfax, USA.
Emanuel PetricoinCenter for Applied Proteomics and Molecular Medicine, George Mason University, Fairfax, USA.
Sandra A JablonskiDepartment of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.
Elana J FertigDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, USA.
Louis M WeinerDepartment of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.ORCID 0000-0001-5192-0710
Georgetown University · USGeorge Mason University · USJohns Hopkins University · USUniversity of California San Diego · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
TARGETED IMMUNOTHERAPY USING BISPECIFIC ANTIBODIESR01CA050633 · NCI · GEORGETOWN UNIVERSITY · PI WEINER, LOUIS M. · 1989 to 2018
$6.5M
NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA050633
6 · The paper itself

Abstract

Targeted monoclonal antibody therapy has emerged as a powerful therapeutic strategy for cancer. However, only a minority of patients have durable responses and the development of resistance remains a major clinical obstacle. Antibody-dependent cell-mediated cytotoxicity (ADCC) represents a crucial therapeutic mechanism of action; however, few studies have explored ADCC resistance. Using multiple

Indexed as

Antibody-Dependent Cell CytotoxicityProteomicsAntibodies, MonoclonalCell Line, TumorHumansKiller Cells, NaturalAntibodies, MonoclonalAntibody-dependent cell-mediated cytotoxicityantibody targetcell surfaceimmunoproteasomeimmunotherapy resistancenatural killer cellsSTAT1

Identifiers

PMID37878417
PMCPMC10601508
OpenAlexW4387935577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.