Evidence map›Paper›PMID 37878364›Full record

ArticleThe Journal of physiology2023

Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats.

Laura Anselmi, Guillaume P Ducrocq, Victor Ruiz-Velasco, Sean D Stocker, Shannon P Higgins, Marc P Kaufman

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Laura AnselmiHeart and Vascular Institute Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0001-8558-1155
Guillaume P DucrocqHeart and Vascular Institute Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0003-3531-4678
Victor Ruiz-VelascoHeart and Vascular Institute Penn State College of Medicine, Hershey, PA, USA.
Sean D StockerDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6317-6300
Shannon P HigginsHeart and Vascular Institute Penn State College of Medicine, Hershey, PA, USA.
Marc P KaufmanHeart and Vascular Institute Penn State College of Medicine, Hershey, PA, USA.
Penn State Milton S. Hershey Medical Center · USMitochondrie, stress oxydant et protection musculaire · FRUniversity of Pittsburgh · US

Funding

Project 3: Role Played by ASIC, P2X and EP4 Receptors in the Exercise Pressor Reflex in Health and Simulated PADP01HL134609 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER · 2017 to 2021
$9.4M
Opioid-induced potentiation of the exercise pressor reflex via acid-sensing ion channels (ASIC3) in health and simulated peripheral artery diseaseR01HL156513 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI RUIZ-VELASCO, VICTOR · 2021 to 2024
$2.4M
Identification of mechano versus chemo-sensitive renal sensory neurons in hypertensionR01HL152680 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2020 to 2023
$2.4M
Role played by Acid Ion Sensing Channels in Peripheral Artery DiseaseR01HL156594 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER, RUIZ-VELASCO, VICTOR · 2021 to 2024
$2.3M
Brain NaCl-sensing in salt-sensitive hypertension.R01HL145875 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2019 to 2022
$2.2M
Broad Bandwidth Transducers for High Resolution Information Rich IVUSR61HL156154 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FLEISCHMAN, AARON J · 2022 to 2023
$761k
Broad Bandwidth Transducers for High Resolution Information Rich IVUSR33HL156154 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FLEISCHMAN, AARON J · 2024 to 2024
$389k
NHLBI NIH HHS P01 HL 134609NHLBI NIH HHS P01 HL134609NHLBI NIH HHS R01 HL145875NHLBI NIH HHS R01 HL152680NHLBI NIH HHS R01 HL 156154NHLBI NIH HHS R01 HL 156513NHLBI NIH HHS R01 HL156513NHLBI NIH HHS R01 HL156594NHLBI NIH HHS R33 HL156154NHLBI NIH HHS R61 HL156154NHLBI NIH HHS RO1 HL 145875NHLBI NIH HHS RO1 HL 152680
6 · The paper itself

Abstract

The role played by the transient receptor potential vanilloid 1 (TRPV1) channel on the thin fibre afferents evoking the exercise pressor reflex is controversial. To shed light on this controversy, we compared the exercise pressor reflex between newly developed TRPV1

Indexed as

CapsaicinTransient Receptor Potential ChannelsAnimalsBlood PressureFemoral ArteryMuscle ContractionMuscle, SkeletalRatsRats, Sprague-DawleyReflexTRPV Cation ChannelsCapsaicinTransient Receptor Potential ChannelsTrpv1 protein, ratTRPV Cation Channelsautonomic nervous systemcapsaicinmetaboreceptorsneural control of the circulationthin fibre muscle afferents

Identifiers

PMID37878364
PMCPMC12042824
OpenAlexW4387931166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.