Potential for using simulated altitude as a means of prehabilitation: a physiology study.

L A Brown, J A Griffiths, P Santer, P M Jakeman, T G Smith

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in Anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

L A BrownRoyal Melbourne Hospital, Melbourne, Australia.

J A GriffithsNuffield Department of Anaesthesia, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

P SanterDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

P M JakemanHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland.

T G SmithCentre for Human and Applied Physiological Sciences, King's College London, London, UK.ORCID 0000-0002-5197-5030

Funding

Academy of Medical SciencesBritish Heart FoundationDiabetes UKMedical Research CouncilVersus ArthritisWellcome Trust

6 · The paper itself

Abstract

The current pandemic of surgical complications necessitates urgent and pragmatic innovation to reduce postoperative morbidity and mortality, which are associated with poor pre-operative fitness and anaemia. Exercise prehabilitation is a compelling strategy, but it has proven difficult to establish that it improves outcomes either in isolation or as part of a multimodal approach. Simulated altitude exposure improves performance in athletes and offers a novel potential means of improving cardiorespiratory and metabolic fitness and alleviating anaemia within the prehabilitation window. We aimed to provide an initial physiological foundation for 'altitude prehabilitation' by determining the physiological effects of one week of simulated altitude (F

Indexed as

AnemiaPreoperative ExerciseAgedAltitudeHumansHypoxiaOxygen Consumptionaltitude traininghaematological fitnesshypoxic conditioningperi-operative medicineprehabilitation

Identifiers

PMID37877784

DOI10.1111/anae.16158

PMCPMC10953332

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.