Evidence map›Paper›PMID 37877723›Full record

ArticlemSphere2023

HPV38 impairs UV-induced transcriptional activation of the IL-18 pro-inflammatory cytokine.

Maria Grazia Ceraolo, Maria Carmen Romero-Medina, Simone Gobbato, Giusi Melita, Hanna Krynska, Cecilia Sirand, Purnima Gupta, Daniele Viarisio, Alexis Robitaille, Jacqueline Marvel and 3 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Maria Grazia Ceraolo *International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Maria Carmen Romero-Medina *International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Simone GobbatoInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Giusi MelitaInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Hanna KrynskaInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Cecilia SirandInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Purnima GuptaInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Daniele ViarisioGerman Cancer Research Center, Heidelberg, Germany.
Alexis RobitailleInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
Jacqueline MarvelCIRI, Centre International de Recherche en Infectiologie, Université Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Université Lyon, Lyon, France.
Massimo Tommasino *IRCCS Istituto Tumori Giovanni Paolo II of Bari, Bari, Italy.
Assunta Venuti *International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.ORCID 0000-0001-5438-1724
Tarik Gheit *International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.ORCID 0000-0001-7088-337X
Centre international de recherche sur le cancer · FRCentre National de la Recherche Scientifique · FRGerman Cancer Research Center · DEIstituto Tumori Bari · ITUniversité Claude Bernard Lyon 1 · FR

Funding

World Health Organization 001
6 · The paper itself

Abstract

importanceHere, we demonstrate that the direct binding of p53 on the IL-18 promoter region regulates its gene expression. However, the presence of E6 and E7 from human papillomavirus type 38 impairs this mechanism via a new inhibitory complex formed by DNA methyltransferase 1 (DNMT1)/PKR/ΔNp73α, which binds to the region formerly occupied by p53 in primary keratinocytes.

Indexed as

CytokinesTumor Suppressor Protein p53HumansInterleukin-18Papillomavirus E7 ProteinsTranscriptional ActivationCytokinesIL18 protein, humanInterleukin-18Papillomavirus E7 ProteinsTumor Suppressor Protein p53HPV38IL-18p53UV irradiationΔNp73α

Identifiers

PMID37877723
PMCPMC10732055
OpenAlexW4387931331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.