Evidence map›Paper›PMID 37877721›Full record

ArticleJournal of virology2023

The master antioxidant defense is activated during EBV latent infection.

Ling Wang, Mary E A Howell, Culton R Hensley, Katharine Ning, Jonathan P Moorman, Zhi Q Yao, Shunbin Ning

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. A putativeFrontiers in immunology · 2026
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ling WangDepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University , Johnson City, Tennessee, USA.ORCID 0000-0001-7861-2769
Mary E A HowellDepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University , Johnson City, Tennessee, USA.
Culton R HensleyDepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University , Johnson City, Tennessee, USA.
Katharine NingDepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University , Johnson City, Tennessee, USA.
Jonathan P MoormanDepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University , Johnson City, Tennessee, USA.
Zhi Q YaoDepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University , Johnson City, Tennessee, USA.ORCID 0000-0002-1333-1007
Shunbin NingDepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University , Johnson City, Tennessee, USA.ORCID 0000-0001-5484-5779
East Tennessee State University · US

Funding

Transcriptional Activation of p62 by the master antioxidant NRF2 in EBV latencyR15CA252986 · NCI · EAST TENNESSEE STATE UNIVERSITY · PI WANG, LING · 2021 to 2023
$522k
Targeting the Oncogenic Transcription Factor IRF4 in Hematological MalignanciesR15DE029621 · NIDCR · EAST TENNESSEE STATE UNIVERSITY · PI NING, SHUNBIN · 2021 to 2021
$447k
LIMD1 Is a Novel Marker Associated with IRF4 in EBV Latency and LymphomaR15DE027314 · NIDCR · EAST TENNESSEE STATE UNIVERSITY · PI NING, SHUNBIN · 2017 to 2017
$444k
NCI NIH HHS R15 CA252986NIDCR NIH HHS R15 DE027314NIDCR NIH HHS R15 DE029621
6 · The paper itself

Abstract

importanceTo our knowledge, this is the first report delineating the activation of the master antioxidant defense during EBV latency. We show that EBV-triggered reactive oxygen species production activates the Keap1-NRF2 pathway in EBV-transformed cells, and LMP1 plays a major role in this event, and the stress-related kinase TBK1 is required for NRF2 activation. Moreover, we show that the Keap1-NRF2 pathway is important for cell proliferation and EBV latency maintenance. Our findings disclose how EBV controls the balance between oxidative stress and antioxidant defense, which greatly improve our understanding of EBV latency and pathogenesis and may be leveraged to opportunities toward the improvement of therapeutic outcomes in EBV-associated diseases.

Indexed as

AntioxidantsEpstein-Barr Virus InfectionsHerpesvirus 4, HumanLatent InfectionVirus LatencyCell ProliferationHumansKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Oxidative StressProtein Serine-Threonine KinasesReactive Oxygen SpeciesViral Matrix ProteinsAntioxidantsEBV-associated membrane antigen, Epstein-Barr virusKEAP1 protein, humanKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2Protein Serine-Threonine KinasesReactive Oxygen SpeciesTBK1 protein, humanViral Matrix Proteinsantioxidant stressEBVKeap1NRF2

Identifiers

PMID37877721
PMCPMC10688347
OpenAlexW4387931109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.