Evidence map›Paper›PMID 37877685›Full record

ArticleEuropean journal of neurology2024

Neurological complications during the Omicron COVID-19 wave in China: A cohort study.

Lu Lu, Lei Chen, Peiyu Wang, Zhang Qi, Yujie Chen, Xintong Wu, Xu Liu, Minjin Wang, Jinmei Li, Bo Yan and 6 more

Abstract read
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lu LuDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0003-3717-5237
Lei ChenDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-5263-5540
Peiyu WangDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-9086-6419
Zhang QiDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-7238-8134
Yujie ChenDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-1056-0840
Xintong WuDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-7676-3288
Xu LiuDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-1620-3932
Minjin WangDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Jinmei LiDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-7411-8269
Bo YanDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Jian GuoDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-5635-8851
Sisi TengDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0009-0008-3414-4375
Weimin LiDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Josemir W SanderDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-6041-9661
Dong ZhouDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-7101-4125
Weixi XiongDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-6835-8664

Funding

International Science and Technology Innovation Cooperation Project of Sichuan Province 2019YFH0196National Key Research and Development Program of China 2021YFC2401201National Natural Science Foundation of China 81901327National Natural Science Foundation of China 82101521National Natural Science Foundation of China U21A20393Natural Science Foundation of Sichuan Province 2022NSFSC1488Science and Technology Innovation Cooperation Project of Sichuan Province Science and Technology Application Demonstration Project of Chengdu Science and Technology Bureau 2019-YF09-00215-SNWest China Hospital, Sichuan University
6 · The paper itself

Abstract

background and purposeThe aim was to investigate the neurological complications associated with coronavirus disease 19 (COVID-19) during the 2022 Omicron wave. METHODS AND ANALYSIS: The medical records of a cohort of people admitted to neurological wards of three participating tertiary centres in Sichuan from 12 December 2022 to 12 January 2023 were reviewed. Demographics and clinical data were obtained and analysed with an interest in COVID-19-related new-onset or worse neurological symptoms. The current data were also compared in two centres with similar data from the same period 12 months earlier.

resultsIn all, 790 people were enrolled, of whom 436 were positive for COVID-19. Ninety-nine had new onset COVID-related neurological problems, or their known neurological condition deteriorated during the wave. There was a significant difference in demographics from the findings amongst admissions 12 months earlier as there was an increase in the average age, the incidence of encephalitis and encephalopathy, and mortality rates. One hundred and one received COVID-specific antivirals, intravenous glucocorticoids and intravenous immunoglobulin therapy. No differences were seen between these and those who did not use them.

conclusionNew-onset neurological conditions, particularly encephalitis and encephalopathy, increased significantly during this period. Deterioration of existing neurological conditions, such as seizure exacerbation, was also observed. A large-scale treatment trial of people with COVID-19 infection presenting with neurological disorders is still needed.

Indexed as

Brain DiseasesCOVID-19EncephalitisChinaCohort StudiesHumansSeizuresencephalitisinpatientSARS-CoV-2

Identifiers

PMID37877685
PMCPMC11235988

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.