SynthesisEmerging infectious diseases2023
Systematic Review and Meta-analysis of Deaths Attributable to Antimicrobial Resistance, Latin America.
Synthesis in Emerging infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Mortality and Length of Stay Associated With Community-Acquired Escherichia coli and Staphylococcus aureus Bloodstream Infections: An Observational Study in 9 Low- and Middle-Income Countries.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Observational
- Targeting histidine biosynthesis in Acinetobacter baumannii: structure-based discovery of natural inhibitors of ATP-phosphoribosyltransferase.Molecular diversity · 2026Article
- When First-Line Therapies Fail: Surgical Site Infections and the Declining Antimicrobial Utility in a Resource-Limited Nation.MicrobiologyOpen · 2026Article
- Environmental reservoirs of carbapenem-resistant organisms in the intensive care unit: a multicenter longitudinal study in two middle-income country hospitals.Antimicrobial resistance and infection control · 2026Article
- Quantifying the Silent Selection Pressure: Antimicrobial Stewardship and Gut Microbiome Integrity in the NICU and PICU.Biomedicines · 2026Article
- Prevalence of Carbapenem-Resistant Gram-Negative Bacilli from Intensive Care Units from Latin America and the Caribbean: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2026Review
- Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study.Infectious diseases and therapy · 2026Article
- Predictors of Mortality inPathogens (Basel, Switzerland) · 2026Review
- Clinical insights into mixedMicrobiology spectrum · 2025Article
- The prevalence and risk of mortality associated with antimicrobial resistance within nosocomial settings-a global systematic review and meta-analysis of over 20,000 patients.EClinicalMedicine · 2025Article
- Article
- Prevalence and mortality associated with multidrug-resistant infections in adult intensive care units in Argentina (PREV-AR).Antimicrobial agents and chemotherapy · 2025Observational
- World Health Organization priority antimicrobial resistance inLancet regional health. Americas · 2025Article
- Antimicrobial resistance burden estimates from the bottom-up: research priorities for estimating the impact of antimicrobial resistance in Brazil.IJID regions · 2025Review
- Exploring the evolution of multidrug resistance patterns in ESKAPEE pathogens using association mining: Key to antibiotic stewardship?Wellcome open research · 2025Article
- Antimicrobial stewardship practices in Guatemala: communication, perceptions, and behaviors regarding antimicrobial prescribing.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- The Use of AgNP-Containing Nanocomposites Based on Galactomannan and κ-Carrageenan for the Creation of Hydrogels with Antiradical Activity.Gels (Basel, Switzerland) · 2024Article
- Antimicrobial resistance inOne health (Amsterdam, Netherlands) · 2024Article
- Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance is a pressing global health concern, leading to 4.95 million deaths in 2019. We conducted a systematic review and meta-analysis to assess the lethality attributed to infections caused by multidrug-resistant organisms (MDROs) in Latin America and the Caribbean. A comprehensive search of major databases retrieved relevant studies from 2000-2022. We included 54 observational studies, primarily from Brazil, Argentina, and Colombia. The most commonly studied organism was methicillin-resistant Staphylococcus aureus. The overall unadjusted case fatality rate related to MDROs was 45.0%; higher adjusted lethality was observed in persons infected with MDROs than in those infected with other pathogens (adjusted odds ratio 1.93, 95% CI 1.58-2.37). A higher lethality rate was seen in patients who did not receive appropriate empirical treatment (odds ratio 2.27, 95% CI 1.44-3.56). These findings underscore the increased lethality associated with antimicrobial resistance in Latin America and the Caribbean.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.