Evidence map›Paper›PMID 37877303›Full record

ReviewCNS oncology2023

Cutaneous T-cell lymphoma with CNS involvement: a case series and review of the literature.

Joshua D Preston, Caroline S Jansen, Siddhartha Kosaraju, Tim Niyogusaba, Tony Z Zhuang, Sally W Iwamoto, Spencer K Hutto, Mary Jo Lechowicz, Pamela B Allen

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in CNS oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Joshua D PrestonMedical Scientist Training Program, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0001-9834-3017
Caroline S JansenMedical Scientist Training Program, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0001-9128-2004
Siddhartha KosarajuDivision of Neuroradiology, Department of Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Tim NiyogusabaDepartment of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0009-0004-5893-4241
Tony Z ZhuangDepartment of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-1729-4629
Sally W IwamotoDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Spencer K HuttoDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-5644-9638
Mary Jo LechowiczDepartment of Hematology & Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Pamela B AllenDepartment of Hematology & Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-3959-3662
Emory University · USMassachusetts General Hospital · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Discriminatory Mechanisms in Early-Onset and Lethal Prostate CancerR01CA264519 · NCI · PUBLIC HEALTH INSTITUTE · PI COHN, BARBARA A, JONES, DEAN PAUL · 2021 to 2025
$1.9M
Examining the Mechanisms of Immune Cell Infiltration and Organization in a Murine Model of Renal Cancer and in Primary Human Renal TumorsF30CA243250 · NCI · EMORY UNIVERSITY · PI JANSEN, CAROLINE STEWART · 2020 to 2023
$214k
Lymphoma Research Foundation 0000059101NCI NIH HHS F30 CA243250NCI NIH HHS F30CA243250, R01CA264519NCI NIH HHS R01 CA264519NIGMS NIH HHS T32 GM008169
6 · The paper itself

Abstract

Cutaneous T-cell lymphoma (CTCL) is a rare hematologic malignancy that traditionally presents with cutaneous lesions, though metastases are not uncommon in progressive disease. We describe four cases of CTCL with central nervous system (CNS) involvement, detailing the history, pathological characteristics, treatment response, and progression. Median time from initial diagnosis to CNS metastasis was ∼5.4 years (range 3.4-15.5 years) and survival after metastasis was ∼160 days (range 19 days-4.4 years). No patients achieved long-term (>5 years) survival, though some displayed varying degrees of remission following CNS-directed therapy. We conclude that clinicians must be attentive to the development of CNS metastases in patients with CTCL. The growing body of literature on such cases will inform evolving therapeutic guidelines on this rare CTCL complication.

Indexed as

Lymphoma, T-Cell, CutaneousNeoplasms, Second PrimarySkin NeoplasmsHumansbrainmetastasismycosis fungoidesSezary syndromevisceral

Identifiers

PMID37877303
PMCPMC10701703
OpenAlexW4387931701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.