Evidence map›Paper›PMID 37877250›Full record

ReviewChemical communications (Cambridge, England)2023

Water-soluble endohedral metallofullerenes: new horizons for biomedical applications.

William P Kopcha, Rohin Biswas, Yue Sun, Sy-Tsong Dean Chueng, Harry C Dorn, Jianyuan Zhang

Open access · greenAbstract readReview
In one paragraph

Review in Chemical communications (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. DFT Calculations of Structure and IR Spectra of GdMolecules (Basel, Switzerland) · 2026
    Article
  2. Metallofullerenol ScAdvanced healthcare materials · 2026
    Article
  3. Review
  4. Inverse Electron Demand Diels-Alder Reaction on MAngewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

William P KopchaDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd., Piscataway, NJ, 08854, USA. jy.zhang@rutgers.edu.
Rohin BiswasDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd., Piscataway, NJ, 08854, USA. jy.zhang@rutgers.edu.
Yue SunDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd., Piscataway, NJ, 08854, USA. jy.zhang@rutgers.edu.
Sy-Tsong Dean ChuengVitale Biotechnology, Inc., 700 West Park Ave., Perkasie, PA, 18944, USA.
Harry C DornDepartment of Chemistry, Virginia Polytechnic Institute and State University, 1040 Drillfield Dr, Blacksburg, VA, 24061, USA. hdorn@vt.edu.ORCID http://orcid.org/0000-0002-3150-5314
Jianyuan ZhangDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd., Piscataway, NJ, 08854, USA. jy.zhang@rutgers.edu.ORCID http://orcid.org/0000-0002-2919-2734
Rutgers, The State University of New Jersey · USVirginia Tech · US

Funding

A Fullerene-based Molecular Route towards Designer NanoparticlesR35GM151131 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Jianyuan Zhang · 2023 to 2026
$1.6M
NIGMS NIH HHS R35 GM151131
6 · The paper itself

Abstract

Endohedral metallofullerenes (EMFs) offer a safe avenue to manipulate metals important to biomedical applications such as MRI contrast, X-ray contrast, radiolabeling, radiotherapy, chemotherapy, and the control of inflammation by scavenging reactive oxygen species (ROS). Moreover, functionalizing the double bonds on the surface of EMFs modifies their solubility, supramolecular behaviour, binding, targeting characteristics, and physical properties. While most existing water-soluble derivatives possess a statistical mixture of appended functional groups, progress has been made in creating molecularly-precise derivatives with a defined number of surface functional groups, leading to potentially more nuanced control of their behaviour and properties. Further elucidation of the structure-function relationships of these materials is expected to enhance their utility in biomedical applications and possibly broaden their use in diverse areas of science and technology.

Indexed as

FullerenesMagnetic Resonance ImagingMetalsSolubilityFullerenesMetals

Identifiers

PMID37877250
PMCPMC11033704
OpenAlexW4387547408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.