Evidence map›Paper›PMID 37877149›Full record

ArticleCombinatorial chemistry & high throughput screening2024

Exploring the Action Mechanism and Validation of the Key Pathways of

Xi Fang, Xiao-Feng Jiang, Yi-Piao Zhang, Cheng-Liang Zhou, Ying-Jie Dong, Bo-Li, Gui-Yuan Lv, Su-Hong Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xi FangCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Gangshu District, Hangzhou, Zhejiang, 310014, China.
Xiao-Feng JiangCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Gangshu District, Hangzhou, Zhejiang, 310014, China.
Yi-Piao ZhangCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Gangshu District, Hangzhou, Zhejiang, 310014, China.
Cheng-Liang ZhouCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Gangshu District, Hangzhou, Zhejiang, 310014, China.
Ying-Jie DongCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Gangshu District, Hangzhou, Zhejiang, 310014, China.
Bo-LiCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Gangshu District, Hangzhou, Zhejiang, 310014, China.
Gui-Yuan LvCollege of Pharmaceutical Science, No. 548, Binwen Road, Binjiang District, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.
Su-Hong ChenCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Gangshu District, Hangzhou, Zhejiang, 310014, China.
Zhejiang University of Technology · CNZhejiang Chinese Medical University · CN

Funding

National Key Research and Development Program of China 2017YFC1702200, 2017YFC1702202National Natural Science Foundation of China 82274134
6 · The paper itself

Abstract

aimThis study investigated the molecular action mechanism of a compound herb, also known as the

methodsThe active ingredients and disease targets of QYF were determined by searching the Batman-TCM and GeneCards databases. Subsequently, the drug-active ingredient-target and protein-protein interaction networks were constructed, and the core targets were obtained through network topology. The Metascape database was screened, and the core targets were enriched with Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes.

resultsIn total, 1403 and 241 potential targets for drugs and diseases, respectively, and 81 intersecting targets were yielded. The core targets included TNF, IL-6, and IL-1β, and the core pathways included PI3K-Akt. The QYF treatment group exhibited effectively improved general signs, enhanced anti-inflammatory ability

conclusionQYF could inhibit LPS production, which regulated the expression of the TLR4/PI3K/Akt/NF-κB signaling pathway to suppress the expression of the related inflammatory factors (i.e., TNF-α, IL-6, and IL-1β), thereby alleviating the CP process.

Indexed as

DendrobiumDrugs, Chinese HerbalNetwork PharmacologyPharyngitisAnimalsAnti-Inflammatory AgentsChronic DiseaseMaleMiceSignal TransductionAnti-Inflammatory AgentsDrugs, Chinese Herbalchronic pharyngitisCP process.Dendrobium officinalenetwork pharmacologythroat-clearingTLR4/PI3K/Akt/NF-κB

Identifiers

PMID37877149
PMCPMC10964081
OpenAlexW4387931186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.