Intratympanic injection of hydrogel nanodrug for the prevention and treatment of sensorineural hearing loss.

Tianying Zhai, Pingping Ai, Zhaohui Tang, Chaoliang He, Xuesi Chen, Shiming Yang, Nan Wu

Abstract readReview

In one paragraph

Review in Journal of otology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tianying ZhaiSenior Department of Otolaryngology-Head & Neck Surgery, PLA General Hospital, Beijing, China.

Pingping AiSenior Department of Otolaryngology-Head & Neck Surgery, PLA General Hospital, Beijing, China.

Zhaohui TangChangchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.

Chaoliang HeChangchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.

Xuesi ChenChangchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.

Shiming YangSenior Department of Otolaryngology-Head & Neck Surgery, PLA General Hospital, Beijing, China.

Nan WuSenior Department of Otolaryngology-Head & Neck Surgery, PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Safe and efficient drug delivery to the inner ear has always been the focus of prevention and treatment of sensorineural deafness. The rapid development of nanodrug delivery systems based on hydrogel has provided a new opportunity. Among them, thermo-sensitive hydrogels promote the development of new dosage form for intratympanic injection. This smart biomaterial could transform to semisolid phase when the temperature increased. Thermo-sensitive hydrogel nanodrug delivery system is expected to achieve safe, efficient, and sustained inner ear drug administration. This article introduces the key techniques and the latest progress in this field.

Indexed as

Intratympanic injectionNanodrugSensorineural hearing lossThermo-sensitive hydrogel

Identifiers

PMID37877070

DOI10.1016/j.joto.2023.09.005

PMCPMC10593563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.