ArticleFrontiers in cellular and infection microbiology2023
Gut microbiota causally affects cholelithiasis: a two-sample Mendelian randomization study.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Gut Microbiome Dysbiosis Promotes Gallstone Formation via Bile Acid Metabolic Disorder: A Multiomics Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Dietary supplementation of glycerol monolaurate improves growth performance, meat quality, and gut microbiota in black pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Inherited immune traits and cisplatin-induced ototoxicity in cancer patients: a Mendelian randomization study.International journal of clinical pharmacy · 2026Article
- Gut microbiota-derived short-chain fatty acids in gallstones: mechanisms and intervention strategies.Frontiers in microbiology · 2026Review
- Gallstone and bile microbiota: A case-control study based on 16S rRNA gene sequencing.World journal of gastrointestinal surgery · 2025Article
- Causal Link of Seven Trace Elements and Eight Nutrients With Meningioma: A Bidirectional Two-Sample Mendelian Randomization Analysis.Brain and behavior · 2025Article
- Association between relative fat mass and risk of gallstones in adults.Scientific reports · 2025Article
- Causal Relationship Between Immune Cells and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.Vascular health and risk management · 2025Article
- Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases.Arthritis research & therapy · 2024Article
- [Causal relationship between gut microbiota and pigmented villonodular synovitis: a Mendelian randomization analysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- The biomedical knowledge graph of symptom phenotype in coronary artery plaque: machine learning-based analysis of real-world clinical data.BioData mining · 2024Article
- Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study.Journal of translational medicine · 2024Article
- Causal relationship between gut microbiota and thyroid nodules: a bidirectional two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Gut microbiota, circulating metabolites, and gallstone disease: a Mendelian randomization study.Frontiers in microbiology · 2024Article
- Assessing causal relationships between gut microbiota and abortion: evidence from two sample Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
- Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota.Frontiers in microbiology · 2024Article
- Gut microbiota influence acute pancreatitis through inflammatory proteins: a Mendelian randomization analysis.Frontiers in cellular and infection microbiology · 2024Article
- Exploring the causal relationship between gut microbiota and multiple myeloma risk based on Mendelian randomization and biological annotation.Frontiers in microbiology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The gut microbiota is closely linked to cholesterol metabolism-related diseases such as obesity and cardiovascular diseases. However, whether gut microbiota plays a causal role in cholelithiasis remains unclear. Aims: This study explored the causal relationship between gut microbiota and cholelithiasis. We hypothesize that the gut microbiota influences cholelithiasis development. Methods: A two-sample Mendelian randomization method was combined with STRING analysis to test this hypothesis. Summary data on gut microbiota and cholelithiasis were obtained from the MiBioGen (n=13,266) and FinnGen R8 consortia (n=334,367), respectively. Results: Conclusion: Gut microbiota causally influences cholelithiasis and may be related to bile salt hydrolases. This work improves our understanding of cholelithiasis causality to facilitate the development of treatment strategies.
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