ArticleJournal of International Society of Preventive & Community Dentistry
Interactive Effect of Salivary Protein Carbonyl, Total Glutathione, pH, and Flow Rate on Root Caries Severity: A Case-Control Study.
Article in Journal of International Society of Preventive & Community Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Association between Live Dietary Microbes and Root Caries: A Cross-Sectional Study with a Predictive Risk Model.Oral health & preventive dentistry · 2026Article
- Environmental particulate matter-one of the culprits in the development of caries.Frontiers in public health · 2025Review
- Dental caries as a health risk for visual acuity in relation to salivary transforming growth factor beta-1 among students aged 8-10 years: A cross-sectional study.Journal of International Society of Preventive & Community DentistryArticle
- Dietary and Salivary Oxidative Status Related to Root Caries Severity: A Case-Control Study.Journal of International Society of Preventive & Community DentistryArticle
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Authors and funding
1 author.
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Abstract
Aims and Objectives: Oxidant and antioxidant components in saliva play an essential role in caries development. The purpose of the current study was to disclose the interactive effect of salivary protein carbonyl (PC), total glutathione (GSH), pH, and flow rate on root caries severity. Materials and Methods: The control and study groups consisted of 90 older adults of both genders classified into six groups: normal salivary flow rate with no root caries (control), normal salivary flow rate with incipient root caries, normal salivary flow rate with shallow root caries, hyposalivation with no root caries, hyposalivation with incipient root caries, and hyposalivation with shallow root caries. Each group consisted of 15 older adults. The study participants were selected from those patients who attended the teaching hospital at the College of the Dentistry/University of Baghdad and fit the study's criteria. Unstimulated saliva was collected. Both salivary pH and flow rate were determined immediately. After that, saliva was subjected to biochemical analysis to determine PC and total GSH levels colorimetrically. Root surface caries was diagnosed clinically using the Root Caries Index. Data were statistically analyzed using descriptive statistics, two-way univariate analysis of variance, two-way multivariate analysis of variance, and Pearson's correlation coefficient ( Results: Salivary total glutathione revealed a significant interactive effect with salivary flow rate and root decay severity. Levels of salivary total GSH were significantly higher in subjects with shallow root caries than those with incipient root caries; no root caries levels of salivary PC were significantly high in the hyposalivation group, but no correlation with caries severity was found. High root caries severity was found to be associated with reduced salivary pH and flow rate. Conclusion: A significant interactive effect was recorded for salivary flow rate, pH, and total GSH on root caries severity except for salivary PC.
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