Evidence map›Paper›PMID 37876555›Full record

ArticleBioactive materials2024

Dual-response of multi-functional microsphere system to ultrasound and microenvironment for enhanced bone defect treatment.

Qingxu Song, Dianwei Wang, Haoyu Li, Zongliang Wang, Songjia Sun, Zhenyu Wang, Yi Liu, Sien Lin, Gang Li, Shaokun Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Tri-Functional MgTA@MnOInternational journal of nanomedicine · 2026
    Article
  6. Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Qingxu SongDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Dianwei WangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Haoyu LiDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Zongliang WangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Songjia SunDepartment of Dermatology, Second Hospital of Jilin University, Changchun, 130022, China.
Zhenyu WangDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Yi LiuDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Sien LinDepartment of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region of China.
Gang LiDepartment of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region of China.
Shaokun ZhangDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Peibiao ZhangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Jilin University · CNChinese Academy of Sciences · CNChinese University of Hong Kong · HKSecond Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using bone tissue engineering strategies to achieve bone defect repair is a promising modality. However, the repair process outcomes are often unsatisfactory. Here we properly designed a multi-functional microsphere system, which could deliver bioactive proteins under the dual response of ultrasound and microenvironment, release microenvironment-responsive products on demand, reverse bone injury microenvironment, regulate the immune microenvironment, and achieve excellent bone defect treatment outcomes. In particular, the MnO

Indexed as

BMP-2Bone defect repairBone injury microenvironmentImmune microenvironmentMulti-functional microsphere

Identifiers

PMID37876555
PMCPMC10590728
OpenAlexW4387732567

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.