Evidence map›Paper›PMID 37876454›Full record

ArticleHeliyon2023

Isoliquiritigenin modulates the activity of LTS and non-LTS cells in the ventrolateral preoptic area via GABA

Sumei Fan, Qiaoling Jin, Pingping Zhang, Dejiao Xu, Juan Cheng, Liecheng Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sumei FanDepartment of Anatomy and Histoembryology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Qiaoling JinDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Pingping ZhangDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Dejiao XuDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Juan ChengDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Liecheng WangDepartment of Anatomy and Histoembryology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Isoliquiritigenin (ILTG) is a chalcone compound that exhibits hypnotic effects via gamma-aminobutyric acid type A (GABA Method: Whole-cell patch-clamp technology was used to detect the firing and currents of LTS and non-LTS cells in the VLPO. Results: Bath administration of ILTG (10 μM) increased the firing rate of VLPO LTS cells, reversed by flumazenil (5 μM), a GABA Conclusions: This study revealed that ILTG suppresses presynaptic GABA release on VLPO LTS cells, thereby increasing their excitability. ILTG enhances postsynaptic GABA

Indexed as

Electrophysiological experimentsGamma-aminobutyric acid type A receptorsIsoliquiritigeninLTS cellsNon-LTS cellsThe ventrolateral preoptic area

Identifiers

PMID37876454
PMCPMC10590785
OpenAlexW4387579831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.