Evidence map›Paper›PMID 37876433›Full record

ArticleHeliyon2023

Mechanistic inhibition of gastric cancer-associated bacteria

Shopnil Akash, Imren Bayıl, Sajjat Mahmood, Nobendu Mukerjee, Tamanna Akter Mili, Kuldeep Dhama, Md Anisur Rahman, Swastika Maitra, Mohamed Mohany, Salim S Al-Rejaie and 3 more

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Research Status and Prospects ofGastroenterology research and practice · 2026
    Review
  3. Article
  4. Article
  5. Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 4 countries.

Shopnil AkashDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Birulia, 1216, Ashulia, Dhaka, Bangladesh.
Imren BayılDepartment of Bioinformatics and Computational Biology, Gaziantep University, Turkey.
Sajjat MahmoodDepartment of Microbiology, Jagannath University, Chittaranjan Avenue in Sadarghat, Dhaka, 1100, Bangladesh.
Nobendu MukerjeeCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute Of Medical and Technical Sciences, Chennai, India.
Tamanna Akter MiliDepartment of Pharmacy, University of Asia Pacific, 74/A Green Rd, Dhaka, 1205, Bangladesh.
Kuldeep DhamaDivision of Pathology, ICAR-Indian Veterinary Research Institute (IVRI), Izatnagar, 243122, Bareilly, Uttar Pradesh, India.
Md Anisur RahmanDepartment of Pharmacy, Islamic University, Kushtia, Bangladesh.
Swastika MaitraDepartment of Microbiology, Adamas University, West Bengal, Kolkata, 700126, India.
Mohamed MohanyDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh, 1145, Saudi Arabia.
Salim S Al-RejaieDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh, 1145, Saudi Arabia.
Nemat AliDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh, 1145, Saudi Arabia.
Prabhakar SemwalDepartment of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, 248002, India.
Rohit SharmaDepartment of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005, India.
King Saud University · SAAdamas University · INBanaras Hindu University · INDaffodil International University · BDGaziantep University · TRGraphic Era University · INIndian Veterinary Research Institute · INIslamic University · BDJagannath University · BDUniversity of Asia Pacific · BDWest Bengal State University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Initiating our study, we curated a list of thirty phytochemicals based on previous literature and subjected them to molecular docking studies. Subsequently, eight phytocompounds-Glabridin, Isoliquiritin, Sanguinarine, Liquiritin, Glycyrrhetic acid, Beta-carotin, Diosgenin, and Sarsasapogenin-were meticulously chosen based on superior binding scores. These were further subjected to an extensive computational analysis encompassing ADMET profiling, drug-likeness evaluation, principal component analysis (PCA), and molecular dynamic simulations (MDs) in comparison with the conventional drug, Mitomycin. Results: The natural compounds investigated demonstrated superior docking affinities to Conclusion: Our comprehensive and technologically-advanced approach showcases the potential of identified phytocompounds as pioneering therapeutic agents against

Indexed as

And PCABinding free energyDrug designGastric cancerHelicobacter pyloriMolecular dockingMolecular dynamic simulationPhytochemicals

Identifiers

PMID37876433
PMCPMC10590806
OpenAlexW4387358623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.