ArticleJournal of the Royal Society, Interface2023
Modularity of biological systems: a link between structure and function.
Article in Journal of the Royal Society, Interface, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- BoolForge: controlled generation and analysis of Boolean functions and networks.Bioinformatics (Oxford, England) · 2026Article
- Improvement in model flexibility reveals signaling pathway in T cell responses to pulsatile stimuli.NPJ systems biology and applications · 2026Article
- Format-Preserving Reduction of Canonical Nonlinear Models.Bulletin of mathematical biology · 2026Article
- Dynamics of attractor transitions in Boolean networks under noise.Chaos (Woodbury, N.Y.) · 2026Article
- Canalization as a stabilizing principle of gene regulatory networks: a discrete dynamical systems perspective.NPJ systems biology and applications · 2026Review
- Novel genes arise from genomic deletions across the bacterial tree of life.bioRxiv : the preprint server for biology · 2026Article
- Attractors are less stable than their basins: Canalization creates a coherence gap in gene regulatory networks.bioRxiv : the preprint server for biology · 2025Article
- Upper bound for the stability of Boolean networks.Physical review. E · 2025Article
- Mapping the attractor landscape of Boolean networks with biobalm.Bioinformatics (Oxford, England) · 2025Article
- Cancer mutationscape: revealing the link between modular restructuring and intervention efficacy among mutations.NPJ systems biology and applications · 2024Article
- Canalization reduces the nonlinearity of regulation in biological networks.NPJ systems biology and applications · 2024Article
- Pancreatic cancer mutationscape: revealing the link between modular restructuring and intervention efficacy amidst common mutations.bioRxiv : the preprint server for biology · 2024Article
- Life's building blocks: the modular path to multiscale complexity.Frontiers in systems biology · 2024Article
- Modularity of biological systems: a link between structure and function.Journal of the Royal Society, Interface · 2023Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
This paper addresses two topics in systems biology, the hypothesis that biological systems are modular and the problem of relating structure and function of biological systems. The focus here is on gene regulatory networks, represented by Boolean network models, a commonly used tool. Most of the research on gene regulatory network modularity has focused on network structure, typically represented through either directed or undirected graphs. But since gene regulation is a highly dynamic process as it determines the function of cells over time, it is natural to consider functional modularity as well. One of the main results is that the structural decomposition of a network into modules induces an analogous decomposition of the dynamic structure, exhibiting a strong relationship between network structure and function. An extensive simulation study provides evidence for the hypothesis that modularity might have evolved to increase phenotypic complexity while maintaining maximal dynamic robustness to external perturbations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.