Evidence map›Paper›PMID 37876230›Full record

ArticleAutophagy2024

Phase transition and lysosomal degradation of expanded CAG repeat RNA suppress global protein synthesis.

Junmei Lu, Yuyin Pan, Xinran Feng, Boxun Lu

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Junmei LuState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, New Cornerstone Science Laboratory, School of Life Sciences, Fudan University, Shanghai, China.ORCID 0000-0002-8592-0556
Yuyin PanState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, New Cornerstone Science Laboratory, School of Life Sciences, Fudan University, Shanghai, China.ORCID 0000-0003-1102-3745
Xinran FengDepartment of Human Genetics, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-6106-8645
Boxun LuState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, New Cornerstone Science Laboratory, School of Life Sciences, Fudan University, Shanghai, China.ORCID 0000-0002-1675-9340
Fudan University · CNShanghai Jiao Tong University · CNUniversity of Chicago · US

Funding

Medical Research Council MR/M023605/1
6 · The paper itself

Abstract

Phase transitions (PT) of biomolecules are heavily involved in neurodegenerative disorders. Almost all previous studies were focusing on the PT of misfolded proteins whereas RNA molecules containing expanded repeats such as the CAG repeats are also able to undergo PT

Indexed as

Huntington DiseaseRNAAnimalsAutophagyGelsHuntingtin ProteinLysosomesMiceTrinucleotide Repeat ExpansionGelsHuntingtin ProteinRNAExpanded CAG repeat RNAhuntington’s diseasephase transitionstranslation

Identifiers

PMID37876230
PMCPMC10813566
OpenAlexW4387930965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.