Evidence map›Paper›PMID 37876033›Full record

ArticleClinical and translational allergy2023

Differential diagnosis between urticarial vasculitis and chronic spontaneous urticaria: An international Delphi survey.

Karoline Krause, Hanna Bonnekoh, Jannis Jelden-Thurm, Riccardo Asero, Ana Maria Gimenez-Arnau, José C Cardoso, Clive Grattan, Emek Kocatürk, Undine Lippert, Marcus Maurer and 4 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 6 countries.

Karoline KrauseInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0001-9711-9654
Hanna BonnekohInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0002-3567-0149
Jannis Jelden-ThurmInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0002-0620-6291
Riccardo AseroAmbulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.ORCID https://orcid.org/0000-0002-8277-1700
Ana Maria Gimenez-ArnauHospital del Mar and Research Institute of Barcelona, Universitat Pompeu Fabra, Barcelona, Spain.ORCID https://orcid.org/0000-0001-5434-7753
José C CardosoDepartment of Dermatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0001-7113-7061
Clive GrattanGuy's Hospital, St John's Institute of Dermatology, London, UK.ORCID https://orcid.org/0000-0002-8466-4351
Emek KocatürkInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0003-2801-0959
Undine LippertDepartment of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
Marcus MaurerInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0002-4121-481X
Martin MetzInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0002-4070-9976
Petra StaubachDepartment of Dermatology, University Medical Center Mainz, Mainz, Germany.
Margarida GoncaloDepartment of Dermatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0001-6842-1360
Pavel KolkhirInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0001-5380-8132
Humboldt-Universität zu Berlin · DEHospitais da Universidade de Coimbra · PTGuy's Hospital · GBJohannes Gutenberg University Mainz · DEKoç University · TROspedale San Carlo · ITUniversitat Pompeu Fabra · ESUniversitätsmedizin Göttingen · DE

Funding

European Academy of Allergy and Clinical Immunology
6 · The paper itself

Abstract

backgroundUrticarial vasculitis (UV) should be differentiated from chronic spontaneous urticaria (CSU) in patients initially presenting with recurrent wheals, although criteria for differential diagnosis remain ill-defined.

objectivesTo set the goals, define criteria and unmet needs in UV diagnosis and differential diagnosis with CSU, and explore the possibility of coexistence of both diseases.

methodsThirteen experts experienced in UV research participated in a Delphi survey of European Academy of Allergy and Clinical Immunology taskforce. This Delphi survey involved three rounds of anonymous responses to n = 32 questions with the aim to aggregate the experts' opinions and to achieve consensus. Urticaria specialists (n = 130, most from Urticaria Centers of Reference and Excellence) evaluated the consensus statements and recommendations in the fourth and final round.

resultsThe panel agreed that essential criteria to guide a skin biopsy in patients with recurrent wheals should include at least one of the following features: wheal duration >24 h, bruising/postinflammatory hyperpigmentation, and systemic symptoms. Leukocytoclasia and fibrin deposits were identified as a minimum set of UV histological criteria. As agreed by the panel members, CSU and normocomplementemic UV (NUV) may coexist in some patients.

conclusionsThe use of established criteria for the diagnosis and differential diagnosis of UV in patients with recurrent wheals can help guide the diagnostic approach and prompt earlier treatment. Further studies should investigate whether CSU and NUV are different entities or part of a disease spectrum.

Indexed as

chronic spontaneous urticariachronic urticariaconsensusdiagnosisdiagnostic criteriaunmet needsurticarial vasculitis

Identifiers

PMID37876033
PMCPMC10587388
OpenAlexW4387824265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.