ArticleInflammation and regeneration2023
CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia.
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Article in Inflammation and regeneration, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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20 citing papers in PubMed, 26 citations in OpenAlex.
- Mesenchyme-derived inflammation during the saccular stage recruits macrophages and alters lung development.JCI insight · 2026Article
- The potential role of CD44+ monocytes in mediating hyperinflammatory response in bronchopulmonary dysplasia in very premature infants.Pediatric research · 2026Article
- Sex-Specific Pathophysiological Signatures in Allometric Dosing-Controlled Bleomycin Acute Lung Injury Model.bioRxiv : the preprint server for biology · 2026Article
- An in utero exposure to the synthetic estrogen diethylstilbestrol affects the fat pad composition in post-natal mammary glands.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- The Value of Cord Blood CXCL10 and MMP8 as Biomarkers in Predicting Bronchopulmonary Dysplasia- A Retrospective Cohort Study.International journal of general medicine · 2026Article
- A Spatiotemporal Model of CXCL10 as a Master Regulator of Immune Evasion and Metastasis in Osteosarcoma.International journal of molecular sciences · 2025Review
- GSDMD deficiency attenuates BPD by suppressing macrophage pyroptosis and promoting M2 polarization.Cell death discovery · 2025Article
- Bronchopulmonary dysplasia: signatures of monocyte-macrophage reactivity and tolerance define novel placenta-lung endotypes.Pediatric research · 2025Article
- Targeting IL6-Edn1-FoxO1 axis enables lung growth in mechanically ventilated newborn mice.The European respiratory journal · 2025Article
- A Novel Model for Simultaneous Evaluation of Hyperoxia-Mediated Brain and Lung Injury in Neonatal Rats.Cells · 2025Article
- Inflammatory factors collaboratively linkFrontiers in immunology · 2025Review
- Safety, Efficacy and Bio-Distribution Analysis of Exosomes Derived From Human Umbilical Cord Mesenchymal Stem Cells for Effective Treatment of Bronchopulmonary Dysplasia by Intranasal Administration in Mice Model.International journal of nanomedicine · 2025Article
- Article
- CXCL4 deficiency limits M4 macrophage infiltration and attenuates hyperoxia-induced lung injury.Molecular medicine (Cambridge, Mass.) · 2024Article
- Macrophage extracellular vesicle-packaged miR-23a-3p impairs maintenance and angiogenic capacity of human endothelial progenitor cells in neonatal hyperoxia-induced lung injury.Stem cell research & therapy · 2024Article
- Bioinformatic analysis reveals the relationship between macrophage infiltration and Cybb downregulation in hyperoxia-induced bronchopulmonary dysplasia.Scientific reports · 2024Article
- Identification of shared immune infiltration characteristic molecules in dermatomyositis and nasopharyngeal carcinoma using bioinformatics: Traits in dermatomyositis and nasopharyngeal cancer.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Kinetics of IFNγ-Induced Cytokines and Development of Immune-Related Adverse Events in Patients Receiving PD-(L)1 Inhibitors.Cancers · 2024Article
- Macrophage Polarizations in the Placenta and Lung are Associated with Bronchopulmonary Dysplasia.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 2 countries.
Dharmesh V Hirani *Department of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Florian Thielen *Department of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Siavash MansouriDepartment of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany.
Soula DanopoulosLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Christina VohlenDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Pinar Haznedar-KarakayaDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Jasmine MohrDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Rebecca WilkeDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Jaco SelleDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Thomas GroschDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Ivana MizikDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Margarete OdenthalCenter for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Faculty of Medicine, and University of Cologne, Cologne, Germany.
Cristina M AlviraDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Celien Kuiper-MakrisDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Gloria S PryhuberDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, NY, USA.
Christian PallaschDepartment I of Internal Medicine, Center for Integrated Oncology (CIO) Köln-Bonn, University of Cologne, Cologne, Germany.
S van Koningsbruggen-RietschelDepartment of Pediatric and Adolescent Medicine, Faculty of Medicine, University Hospital Cologne, and University of Cologne, Cologne, Germany.
Denise Al-AlamLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Werner SeegerUniversities of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Institute for Lung Health (ILH) and Cardio-Pulmonary Institute (CPI), Gießen, Germany.
Rajkumar SavaiUniversities of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Institute for Lung Health (ILH) and Cardio-Pulmonary Institute (CPI), Gießen, Germany.
Jörg DötschDepartment of Pediatric and Adolescent Medicine, Faculty of Medicine, University Hospital Cologne, and University of Cologne, Cologne, Germany.
Miguel A Alejandre AlcazarDepartment of Pediatric and Adolescent Medicine, Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany. miguel.alejandre-alcazar@uk-koeln.de.ORCID http://orcid.org/0000-0002-3176-0411
University of Cologne · DEMax Planck Institute for Heart and Lung Research · DEUCLA Medical Center · USStanford University · USUniversity of Rochester Medical Center · US
Funding
BioRepository for INvestigation of Diseases of the Lung (BRINDL) - Phase IIIU01HL148861 · NHLBI · UNIVERSITY OF ROCHESTER · PI GLORIA S PRYHUBER · 2019 to 2026
$9.7MMolecular Atlas of Lung Development - Data Coordinating CenterU01HL122638 · NHLBI · DUKE UNIVERSITY · PI CLARK, ROBERT F, PALMER, SCOTT M · 2014 to 2018
$7.5MMolecular anatomy of human alveolar developmentU01HL122681 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WARBURTON, DAVID · 2014 to 2018
$4.0MDevelopmental Heterogeneity of Pulmonary Endothelial Phenotype at Single Cell ResolutionR01HL154002 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVIRA, CRISTINA MARIA · 2021 to 2024
$2.8MDiverse Homeostatic Roles for Distinct Macrophages in the Developing Lung VasculatureR01HL155828 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVIRA, CRISTINA MARIA · 2021 to 2024
$2.6MPericytes and postnatal alveolarization: Role of hypoxia inducible factorsR01HL160018 · NHLBI · STANFORD UNIVERSITY · PI ALVIRA, CRISTINA MARIA, CORNFIELD, DAVID N. · 2022 to 2025
$2.6MMechanisms controlling early human lung developmentR01HL141856 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI AL-ALAM, DENISE · 2018 to 2022
$2.5MNHLBI NIH HHS 1U01HL122638NHLBI NIH HHS 1U01HL122700NHLBI NIH HHS R01 HL141856NHLBI NIH HHS R01 HL154002NHLBI NIH HHS R01 HL155828NHLBI NIH HHS R01 HL160018NHLBI NIH HHS U01 HL122638NHLBI NIH HHS U01HL122681NHLBI NIH HHS U01 HL148861NIH HHS R01HL141856
Abstract
Preterm infants with oxygen supplementation are at high risk for bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease. Inflammation with macrophage activation is central to the pathogenesis of BPD. CXCL10, a chemotactic and pro-inflammatory chemokine, is elevated in the lungs of infants evolving BPD and in hyperoxia-based BPD in mice. Here, we tested if CXCL10 deficiency preserves lung growth after neonatal hyperoxia by preventing macrophage activation. To this end, we exposed Cxcl10 knockout (Cxcl10
Indexed as
Bronchopulmonary dysplasiaCollagenCXCL10Elastic fibersHyperoxiaLung matrix remodeling
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