ArticleDiabetology & metabolic syndrome2023
The association of metabolic syndrome with rotator cuff tendinopathy: a two-sample Mendelian randomization study.
Article in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07645963 (Effects of Myofascial Trigger Point Release Versus Neil Asher Technique on Pain, Range of Motion, and Disability in Patients With Rotator Cuff Syndrome), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Myofascial Trigger Point Release Versus Neil Asher Technique on Pain, Range of Motion, and Disability in Patients With Rotator Cuff Syndrome
Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Exploring the shared genetic architecture between periodontitis and cardiovascular disease.BDJ open · 2026Article
- Predicting Major Preoperative Risk Factors for Retears After Arthroscopic Rotator Cuff Repair Using Machine Learning Algorithms.Journal of clinical medicine · 2025Article
- Two-Sample Bidirectional Mendelian Randomization Study With Causal Association Between Metabolic Syndrome and Cerebral Aneurysm.Brain and behavior · 2025Article
- A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.Frontiers in genetics · 2024Article
- Lipids, lipid-lowering drugs and lateral epicondylitis of the humerus: a drug-targeted Mendelian randomization study.Frontiers in genetics · 2024Article
- Genetically proxied inhibition of kidney function pathways and increased risk of type 2 diabetes in Africans: A Mendelian randomization study.Science progressArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObservational research reported the underlying correlation of metabolic syndrome (MetS) and its components with rotator cuff tendinopathy (RCT), but their causality remained unclear. This study aimed to investigate whether genetically predicted MetS was related to the risk of RCT.
methodsBoth univariable and multivariable Mendelian randomization (MR) analysis was applied using summary-level data from the most comprehensive genome-wide association studies to estimate the associations of MetS and its component with RCT, with the inverse variance weighted (IVW) as the primary method, and the method of Causal Analysis Using Summary Effect Estimates (CAUSE) as a supplement for false positives detection. The mediation analysis was furtherly used for the assessment of direct and indirect effects.
resultsUnivariable analysis revealed that genetically predicted MetS (OR: 1.0793; 95% CI 1.0311 to 1.1297), body mass index (BMI) (OR 1.2239; 95% CI 1.1357 to 1.3189), and waist circumference (WAC) (OR 1.3177; 95% CI 1.2015 to 1.4451) had a significant positive association with the risk of RCT. Triglycerides and systolic blood pressure were suggestively associated with RCT risk. These associations were also identified by CAUSE. There was independent causality of BMI (OR: 1.1806; 95% CI 1.0788 to 1.2920) and WAC (OR 1.3716; 95% CI 1.2076 to 1.5580) on RCT after adjustment for confounders. No mediator was found in the causal associations.
conclusionOur study revealed the genetic causality of MetS and its components, especially BMI and WAC, with RCT risk. Early prevention and diagnosis of excess central adiposity contributing to MetS are significant in the RCT risk management.
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