SynthesisBMC genomics2023
Genetic influences on alcohol flushing in East Asian populations.
Synthesis in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Effect ofBJPsych open · 2026Article
- A Body Shape Index and asthma prevalence in Chinese middle-aged and older adults: a cross-sectional study.BMC pulmonary medicine · 2026Article
- Genetic Polymorphisms ofInternational journal of molecular sciences · 2025Review
- The GeoTox Package: open-source software for connecting spatiotemporal exposure to individual and population-level risk.Human genomics · 2025Article
- The Role of the 5-HTTLPR Gene Variation of the SLC6A4 Serotonergic System in the Development of Addictive Disorders: A Narrative Review.Consortium psychiatricum · 2025Review
- The GeoTox Package: Open-source software for connecting spatiotemporal exposure to individual and population-level risk.medRxiv : the preprint server for health sciences · 2024Article
- Association Between Asian Flush and Satisfaction of Sleep via Alcohol Consumption Status in a Sample of Japanese Participants.Medical sciences (Basel, Switzerland) · 2024Article
- Asian flush is a potential protective factor against COVID-19: a web-based retrospective survey in Japan.Environmental health and preventive medicine · 2024Article
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundAlthough it is known that variation in the aldehyde dehydrogenase 2 (ALDH2) gene family influences the East Asian alcohol flushing response, knowledge about other genetic variants that affect flushing symptoms is limited.
methodsWe performed a genome-wide association study meta-analysis and heritability analysis of alcohol flushing in 15,105 males of East Asian ancestry (Koreans and Chinese) to identify genetic associations with alcohol flushing. We also evaluated whether self-reported flushing can be used as an instrumental variable for alcohol intake.
resultsWe identified variants in the region of ALDH2 strongly associated with alcohol flushing, replicating previous studies conducted in East Asian populations. Additionally, we identified variants in the alcohol dehydrogenase 1B (ADH1B) gene region associated with alcohol flushing. Several novel variants were identified after adjustment for the lead variants (ALDH2-rs671 and ADH1B-rs1229984), which need to be confirmed in larger studies. The estimated SNP-heritability on the liability scale was 13% (S.E. = 4%) for flushing, but the heritability estimate decreased to 6% (S.E. = 4%) when the effects of the lead variants were controlled for. Genetic instrumentation of higher alcohol intake using these variants recapitulated known associations of alcohol intake with hypertension. Using self-reported alcohol flushing as an instrument gave a similar association pattern of higher alcohol intake and cardiovascular disease-related traits (e.g. stroke).
conclusionThis study confirms that ALDH2-rs671 and ADH1B-rs1229984 are associated with alcohol flushing in East Asian populations. Our findings also suggest that self-reported alcohol flushing can be used as an instrumental variable in future studies of alcohol consumption.
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