ArticleEuropean radiology experimental2023
Photon-counting detector CT-based virtual monoenergetic reconstructions: repeatability and reproducibility of radiomics features of an organic phantom and human myocardium.
Article in European radiology experimental, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of photon-counting CT angiography with energy-integrating CT angiography in coronary artery stenosis: a systematic review and meta-analysis.BMC medical imaging · 2025Pooled it
- Evaluation of a CZT-based photon-counting detector CT prototype for low-dose lung cancer screening using patient-specific lung phantoms.Research square · 2026Article
- Impact of Different Energy Levels of Virtual Monoenergetic Reconstructions on Radiomic Features Stability in Organic Phantom Imaging Using Photon-Counting CT.Tomography (Ann Arbor, Mich.) · 2026Article
- Development and validation of a machine learning-based radiomics model using 45-keV virtual monoenergetic images for differentiating fat-poor angiomyolipoma from clear cell renal cell carcinoma.Translational andrology and urology · 2026Article
- Cardiac imaging using photon counting CT - benefits, challenges and prospects.The international journal of cardiovascular imaging · 2026Review
- Evaluation of a CZT-based photon-counting detector CT prototype for low-dose lung cancer screening using patient-specific lung phantoms.medRxiv : the preprint server for health sciences · 2025Article
- A Narrative Review of Photon-Counting CT and Radiomics in Cardiothoracic Imaging: A Promising Match?Diagnostics (Basel, Switzerland) · 2025Review
- Association between epicardial adipose tissue imaging characteristics and left atrial appendage thrombus in patients with atrial fibrillation.International journal of cardiology. Heart & vasculature · 2025Article
- Stenosis quantification in high-pitch photon-counting coronary CT angiography: in vitro and in vivo impact of reconstruction kernel types and sharpness levels.European radiology experimental · 2025Article
- Robustness of radiomics within photon-counting detector CT: impact of acquisition and reconstruction factors.European radiology · 2025Article
- Photon-counting detector CT: a disrupting innovation in medical imaging.European radiology experimental · 2025Article
- Robustness of radiomics among photon-counting detector CT and dual-energy CT systems: a texture phantom study.European radiology · 2025Article
- Value of Ultrahigh-Resolution Photon-Counting Detector Computed Tomography in Cardiac Imaging.Echocardiography (Mount Kisco, N.Y.) · 2025Review
- Radiomics Feature Stability in True and Virtual Non-Contrast Reconstructions from Cardiac Photon-Counting Detector CT Datasets.Diagnostics (Basel, Switzerland) · 2024Article
- Competence and contributions of radiologists to cardiac CT and MR imaging across Europe.European radiology · 2024Article
- Intraindividual reproducibility of myocardial radiomic features between energy-integrating detector and photon-counting detector CT angiography.European radiology experimental · 2024Article
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13 authors.
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Abstract
backgroundPhoton-counting detector computed tomography (PCD-CT) may influence imaging characteristics for various clinical conditions due to higher signal and contrast-to-noise ratio in virtual monoenergetic images (VMI). Radiomics analysis relies on quantification of image characteristics. We evaluated the impact of different VMI reconstructions on radiomic features in in vitro and in vivo PCD-CT datasets.
methodsAn organic phantom consisting of twelve samples (four oranges, four onions, and four apples) was scanned five times. Twenty-three patients who had undergone coronary computed tomography angiography on a first generation PCD-CT system with the same image acquisitions were analyzed. VMIs were reconstructed at 6 keV levels (40, 55, 70, 90, 120, and 190 keV). The phantoms and the patients' left ventricular myocardium (LVM) were segmented for all reconstructions. Ninety-three original radiomic features were extracted. Repeatability and reproducibility were evaluated through intraclass correlations coefficient (ICC) and post hoc paired samples ANOVA t test.
resultsThere was excellent repeatability for radiomic features in phantom scans (all ICC = 1.00). Among all VMIs, 36/93 radiomic features (38.7%) in apples, 28/93 (30.1%) in oranges, and 33/93 (35.5%) in onions were not significantly different. For LVM, the percentage of stable features was high between VMIs ≥ 90 keV (90 versus 120 keV, 77.4%; 90 versus 190 keV, 83.9%; 120 versus 190 keV, 89.3%), while comparison to lower VMI levels led to fewer reproducible features (40 versus 55 keV, 8.6%).
conclusionsVMI levels influence the stability of radiomic features in an organic phantom and patients' LVM; stability decreases considerably below 90 keV. RELEVANCE STATEMENT: Spectral reconstructions significantly influence radiomic features in vitro and in vivo, necessitating standardization and careful attention to these reconstruction parameters before clinical implementation. KEY POINTS: • Radiomic features have an excellent repeatability within the same PCD-CT acquisition and reconstruction. • Differences in VMI lead to decreased reproducibility for radiomic features. • VMI ≥ 90 keV increased the reproducibility of the radiomic features.
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